Histone Deacetylase Inhibitors Research

Evidence that an HDAC2-targeted ASO persistently upregulates cortical acetylcholine and dopamine signaling via a CREB | Gs positive feedback loop

The paper shows that inhibiting HDAC2 with ASOs increases cortical acetylcholine and dopamine signaling via a CREB-Gs positive feedback loop, enhancing cognition.

The critical role of HDAC1 activates NSCLC growth by nicotine resistance Cisplatin

This study identifies HDAC1 as a mediator of nicotine-induced cisplatin resistance in NSCLC cells, showing nicotine promotes growth by targeting HDAC1 and modulating E2F and Cyclin E expression.

Differential complex formation via paralogs in the human Sin3 protein interaction network.

The paper investigates how paralog switching affects Sin3 complex interaction networks in humans, revealing shared and distinct interactions between SIN3A and SIN3B.

The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program

This study identifies MiDAC as a regulator of neurodevelopmental gene expression by modulating histone acetylation and neurite outgrowth.

Exogenous and endogenous HDAC inhibitor effects in Rubinstein-Taybi syndrome models

This study investigates the effects of HDAC inhibitors in RSTS models, showing molecular rescue and microbiota changes, and highlights the role of gut microbiota in chromatinopathy.

HDAC6 promotes PMA-induced megakaryocyte differentiation of K562 cells by regulating ROS levels via NOX4 and repressing Glycophorin A

This study shows HDAC6 promotes PMA-induced megakaryocyte differentiation in K562 cells by increasing ROS via NOX4 and repressing the erythroid marker GYPA.