Nicotinic Acetylcholine Receptors Study

The paper identifies α9-containing nicotinic acetylcholine receptors (α9* nAChRs) at the zebrafish lateral line efferent synapse, showing they mediate ACh-induced inhibition of hair cell activity through SK potassium channels.

This study shows that Chrna5 enables rapid and resilient cholinergic responses in prefrontal cortex, crucial for attention, and identifies NS9283 as a potential treatment for Chrna5 disruption.

This study shows that PKCε regulates Chrna6 and Chrnb3 expression differently in male and female mice, affecting nicotine and alcohol behavior.

This study quantifies post-synaptic NMJ morphology in different mouse muscles and finds it correlates with fibre type, not diameter, and shows NMJ growth rates vary across muscles.

This study shows that sazetidine-A, a nAChR agonist, enhances alcohol aversion in mice by acting on non-4 nAChRs, reducing binge drinking without affecting nicotine consumption.

This study examines how repeated nicotine exposure affects dopamine release in the nucleus accumbens of rats and links these changes to locomotor sensitization and vulnerability to substance use disorder.

The paper investigates the distinct roles of alpha-7 and alpha-4/beta-2 nicotinic acetylcholine receptor agonists in learning and attentional filtering using nonhuman primates, finding a double dissociation in their effects.

The paper compares evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors across tetrapods, finding distinct patterns in sequence conservation, co-expression, and functional properties.

This study examines the effects of alpha7 nAChR agonists and PAMs on neuronal firing activity and NMDA-evoked responses in rat CA1 hippocampal pyramidal cells in vivo.

The paper investigates how ACh signaling defects in eat-2 mutants affect peristalsis and finds that crosstalk with GAR-3 receptors contributes to feeding defects and lifespan changes.

This study shows that somatic nicotinic acetylcholine receptors in VTA dopamine neurons modulate firing properties and reward-related behaviors through optical manipulation.

This study shows that VTA glutamate neurons express nicotinic acetylcholine receptors and are modulated by cholinergic input, affecting excitatory transmission.

This study uses PET imaging with [18F]ASEM to assess reproducibility, occupancy, receptor density, and changes in a7-nAChR in schizophrenia patients.