FOXO transcription factor regulation

Canonical insulin-like receptor DAF-2 signaling-independent patterning and role for FoxO/DAF-16 in early embryos

This study identifies germ lineage-specific DAF-16 patterning and a role for DAF-16 in early embryogenesis independent of canonical DAF-2 signaling.

FoxO transcription factors couple the urea cycle and gluconeogenesis by controlling Ass1

This study identifies FoxO transcription factors as regulators of Ass1, linking urea cycle and gluconeogenesis during fasting.

DAF-16/FOXO maintains genome integrity following genotoxic stress

This study shows DAF-16/FOXO maintains genome integrity in C. elegans by activating DDR repair genes and functioning both cell-autonomously and non-autonomously.

FOXO1 inhibition and FADD knockdown have opposing effects on anticancer drug-induced cytotoxicity and p21 expression in osteosarcoma

This study shows FOXO1 inhibition reduces anticancer drug cytotoxicity and increases p21, while FADD knockdown enhances cytotoxicity and reverses p21 upregulation in osteosarcoma.

Gene model for the ortholog of foxo in Drosophila sechellia

The paper provides a gene model for the foxo ortholog in Drosophila sechellia using a standardized annotation protocol.

DNA-binding-independent mechanisms of metabolic regulation by the Drosophila FOXO transcription factor

This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.

Disrupting FOXO4 function confers neuroprotection against oxidative stress and ischemia-reperfusion-caused neuronal injury

This study shows that disrupting FOXO4 function reduces oxidative stress and neuronal injury in ischemia-reperfusion conditions, suggesting it as a therapeutic target for stroke.

Patterning, regulation, and role of FoxO/DAF-16 in the early embryo

This study investigates the spatial and temporal dynamics of FoxO/DAF-16 in C. elegans embryos and its role in cell cycle regulation during early development.

A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage

The paper shows that FOXO/DAF-16 mediates cell non-autonomous germline quality control in response to somatic DNA damage in C. elegans, ensuring progeny fitness.

The transcription factor FoxO1 is required for the establishment of the human definitive endoderm

This study shows FoxO1 is essential for human definitive endoderm formation by regulating gene expression during hepatocyte differentiation.