Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
8 papers
Onur Deniz, Liu Y, Tuuli Kirkinen, Krista Kokki, Kateryna Gaertner, Pau Clavell-Revelles, Jaakko Mattila, Ville Hietakangas
This study identifies Spalt-related (Salr) as a negative regulator of growth and lipid storage, activated through the integrated stress response and converging with FoxO to promote catabolism during nutrient stress.
The EMBO Journal · Jul 11, 2026Peer-reviewedCell Biology
Shifei Wu, Jinghua Gao, Yan Li, Charline Roy, Y Wang, Ben Mulcahy, William Li, Sruthy Ravivarma, John A. Calarco, Wesley Hung, Mei Zhen
The paper identifies three muscle-specific DAF-16/FOXO targets activated by reduced insulin/IGF-1 signaling in C. elegans through transcriptomic and chromatin analyses.
G3 Genes Genomes Genetics · Mar 3, 2026Peer-reviewedGenomics
Matthew J. Wirick, Allison R. Cale, Isaac T. Smith, Amelia F. Alessi, Margaret R. Starostik, Liberta Cuko, Kyal Lalk, Mikayla N. Schmidt, Benjamin S. Olson, Payton M. Salomon, Alexis Santos, Axel D. Schmitter-Sánchez, Himani Galagali, Kevin J. Ranke, Payton Wolbert, , Xantha Karp
This study shows that daf-16/FOXO promotes multipotency in C. elegans dauer larvae by upregulating lin-41/TRIM71, which blocks premature adult cell fate markers.
PLoS Genetics · Nov 15, 2021Peer-reviewedGenetics
Takumi Kitamoto, Taiyi Kuo, Atsushi Okabe, Atsushi Kaneda, Domenico Accili
This paper investigates the transcriptional regulation of lipid and glucose metabolic genes in hepatic insulin resistance, finding distinct regulatory patterns and a model for their coexistence in type 2 diabetes.
Proceedings of the National Academy of Sciences · Nov 3, 2021Peer-reviewedMolecular Biology
Marten Hornsveld, Femke M. Feringa, Lenno Krenning, Jeroen van den Berg, Lydia M.M. Smits, Nguyen BT Nguyen, Maria J. Rodríguez Colman, Tobias B. Dansen, René H. Medema, Boudewijn M.T. Burgering
The paper identifies a FOXO-dependent mechanism that restricts proliferation of cells with mild replication stress by promoting premature activation of APC/CCDH1.
Cell Reports · Jan 1, 2021Peer-reviewedMolecular Biology
Fan Zhang, Mehdi Pirooznia, Hong Xu
This study shows that disrupting mitochondrial electron transport chain (ETC) in Drosophila intestinal stem cells (ISCs) impairs their differentiation, likely through increased FOXO signaling.
Molecular Biology of the Cell · Jun 29, 2020Peer-reviewedDevelopmental Biology
Allison Birnbaum, Xiaofen Wu, Marc Tatar, Nan Liu, Hua Bai
This study investigates age-related changes in FOXO transcription factor gene targeting in Drosophila melanogaster using ChIP-Seq, revealing a decline in FOXO-bound genes and shifts in targeted biological processes with age.
Frontiers in Genetics · May 7, 2019Peer-reviewedGenomics
Ping Kang, Kai Chang, Ying Liu, Mark J Bouska, Allison Birnbaum, Galina Karashchuk, Rachel V. Thakore, Wenjing Zheng, Stephanie Post, Colin S. Brent, Sheng Li, Marc Tatar, Hua Bai
This study identifies a physical and genetic interaction between dFOXO and Kr-h1 in Drosophila, showing that Kr-h1 represses lipolysis by regulating adipose lipase brummer transcription.
Scientific Reports · Nov 21, 2017Peer-reviewedGenetics