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This study reports cryo-EM structures of human PAT-1 with inhibitors to elucidate their inhibition mechanisms and domain interactions.

This study develops tetrasulfide-incorporated mesoporous silica nanoparticles to enhance mRNA delivery by optimizing morphology and chemistry, showing improved cellular uptake and mRNA stability.

The paper measures basal activity across the human GPCR family on a single scale and identifies key residues that influence constitutive signaling.

This paper introduces RAD-seq, a method to quantify RNA accessibility by protein binding, and shows it can detect RBP footprints and RNA structure changes under stress.

This study investigates coenzyme specificity in yeast GDH3, showing how mutations alter coenzyme preference and revealing structural and evolutionary mechanisms of coenzyme regulation.

This study uses Aggregate Deep Visual Proteomics to show that α-synuclein inclusions selectively concentrate specific proteins in neurons, revealing their formation mechanisms and potential therapeutic targets.

This study reconstitutes OATP1B1 and OATP1B3 in proteoliposomes to show bicarbonate gradients drive substrate uptake, with EGCG enhancing OATP1B3 transport.

This study identifies GNG2 as an inhibitor of the SMP complex by binding MRAS, disrupting its assembly and inhibiting MAPK signaling.

This study shows that the basic segment of the AtVLN4 linker bundles actin filaments and is influenced by temperature and potassium ions.

This study determines the cryo-EM structures of Cereibacter sphaeroides ferrochelatase, revealing oligomeric states that occlude the substrate-binding site.

This study identifies a respiratory microdomain in Toxoplasma gondii that links ubiquinone biosynthesis to succinate dehydrogenase, revealing a unique mitochondrial organization lacking complex I.

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

The paper maps bacterial bile amidation by analyzing BSH transaminase activities and identifying BBAs in human samples.

The paper identifies a bacterial pathway, Cerberus, that uses DNA damage sensing to regulate defense operon expression through anti-sigma factor cleavage.

This study identifies KNL1 as a key driver of chromosomal instability and immune evasion in HCC through integrative bioinformatics and CRISPR-Cas9 experiments.

This study shows that heterogeneous primary nucleation at surfaces determines the fibril structure of Aβ42, with different structures formed in identical solutions depending on the surface type.

QC-espresso provides an automated quality-control workflow for DIA proteomics data, generating structured reports to assess acquisition quality and quantitative reliability.

This study investigates how different molecular crowders affect the magnetic field-dependent fluorescence and recovery kinetics of MagLOV2 in E. coli lysate.

The paper identifies cyclic peptides that selectively bind to a cotranslational folding intermediate of β-galactosidase, revealing a druggable pocket formed during translation.

The paper shows Scm3HJURP facilitates Cse4CENP-A deposition at native centromeres by interacting with Ndc10, enhancing Cse4 assembly efficiency in yeast.