Discover, rate, and discuss biology preprints.

This paper uses protein language models to discover new-to-nature protein domains with structures outside known CATH superfamilies, suggesting natural protein structure-space is incomplete.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.

This paper demonstrates that multiparametric QPI can assess drug sensitivity in patient-derived breast cancer models, including cryopreserved samples, revealing cellular heterogeneity and resistance mechanisms.

The paper introduces Kanzi, a flow-based tokenizer for protein structures that simplifies training and outperforms existing tokenizers on reconstruction metrics.

The paper designs multiclade coronavirus spike immunodominant domain nanoparticles that elicit broad antibody responses against multiple EhCoVs and SARS-CoV-2 variants in mice.

This paper introduces SONIC, a benchmarking paradigm for BCIs, demonstrating an ITR of over 200 bps using an ovine model and the Connexus BCI.

This paper introduces Caliby, a sequence design method that conditions on structural ensembles to improve designability while reducing native sequence recovery.

LabscriptAI translates natural language into robot scripts for synthetic biology, achieving high simulation accuracy and enabling secure, standardized, and traceable lab automation.

This study shows that PSA-MAP scaffolds enhance early neural regeneration after ischemic stroke by increasing progenitor cells and axonal content without significant changes in astrocytic or vascular coverage.

This study enhances mRNA translation efficiency by engineering Kozak repeats in the 5'-UTR, showing improved expression in both cell culture and mice.

This study uses protein language models and Bayesian optimization to improve protein engineering efficiency by predicting function from sequences and optimizing variant search.

This study observes crack propagation in human bone under fatigue loading, revealing nanoscale mechanisms that decelerate crack growth and suppress damage accumulation.

This study assesses acute kidney injury in a neonatal rat model of necrotizing enterocolitis using photoacoustic imaging and finds reduced renal oxygen saturation as a non-invasive biomarker.

This paper evaluates the effects of DMSO cryopreservation on human cerebrovascular tissue biomechanics and histology, finding it fails to consistently protect tissue integrity and increases elastin fractures.

This paper introduces a scalable fabrication platform for magnetic microrobots capable of precise intracorporeal navigation, validated in multiple models and demonstrating potential for precision medicine applications.

This paper proposes a non-invasive microrobotic embryo transfer technique using magnetically actuated microcarriers to improve embryo delivery in assisted reproduction, enabling precise, image-guided delivery with minimal invasiveness.

This paper develops Apt-circRNAs for targeted antigen-presenting cell immunotherapy, showing efficacy in tumors and clinical trials.

The paper introduces A-PACE, an open-source toolkit for real-time electrochemical data analysis, improving peak detection, baseline fitting, and data processing efficiency.

The paper introduces T-PGI, a system for scarless, programmable genome integration, showing high-fidelity insertion with minimal structural variants.

This paper shows that periplasmic expression of GFP variants like sfGFP harms E. coli physiology, limiting their use as screening tools for recombinant protein production.