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This study optimizes velocity receptor (VR) transduction in CAR T cells by evaluating vector modifications and transduction efficiency, finding that VR5IL8 and VR5TNF perform best.

This paper enhances laser lithotripsy efficiency using a PEDOT:PSS nanofluid, achieving significant improvements in stone ablation without increased thermal injury.

This study demonstrates that peptide amphiphile nanostructures enhance cancer imaging and therapy by hitchhiking on endogenous biomolecules to target tumors effectively.

This paper develops tumor-targeting gene drive vectors that eliminate drug resistance in solid tumors through systemic delivery, showing durable tumor burden reduction with minimal toxicity.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

This study develops a combined coating method for dendritic cell membrane-coated nanoparticles, showing improved protein coating and size control, and validates their antigen-specific T cell engagement.

This paper proposes and evaluates C3.5 photosynthesis, a novel strategy to enhance Rubisco efficiency by coupling mitochondrial bioenergetics to chloroplast carbon assimilation in Arabidopsis.

The paper develops bioengineered human tonsil organoids (BTOs) to study immune functions, showing they support antigen-specific responses and immune-stromal interactions comparable to native tissues.

This study evaluates anaerobic co-digestion of sewage sludge and food waste using single- and two-stage reactors with and without carriers, finding that two-stage systems with carriers achieve the highest biogas production and stability.

This study identifies markers distinguishing TIL expansion properties and develops SIN-based strategies to enhance expansion and activation of both low- and high-expanding TILs.

This study develops a data-driven model to estimate joint-space inertia of the lower limb during locomotion, showing improved accuracy compared to rigid body models.

This study identifies sex-based differences in integrin expression and endothelial cell adhesion to bioactive hydrogels, highlighting the need to consider biological sex in biomaterial design.

This study uses liquid TEM to visualize the three-step mineralization process of calcium phosphate on titanium dioxide nanoparticles, revealing dynamic structural changes and electron beam effects.

miniVec is a new plasmid backbone that eliminates antibiotic resistance genes and improves plasmid yield and functionality for clinical applications.

This paper uses protein language models to discover new-to-nature protein domains with structures outside known CATH superfamilies, suggesting natural protein structure-space is incomplete.

This study develops a microfluidic model to investigate how pulsatile fluid flow affects 3D osteocyte networks, showing mechanotransduction via calcium signals and sustained gene expression.

This paper develops a personalized multiscale model of left atrial mechanics and blood flow to simulate deformation and hemodynamics using patient-specific data.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.

This paper demonstrates that multiparametric QPI can assess drug sensitivity in patient-derived breast cancer models, including cryopreserved samples, revealing cellular heterogeneity and resistance mechanisms.

This study investigates how varying ultrasound parameters affect neural activity in rat sciatic nerves, finding that cumulative energy exposure determines excitation or suppression of motor responses.