Discover, rate, and discuss biology preprints.

This study develops a decellularized meniscus biomaterial (MEND) that supports stem cell invasion and chondrogenesis, showing comparable performance to existing tissue engineering materials.

This paper evaluates the effects of DMSO cryopreservation on human cerebrovascular tissue biomechanics and histology, finding it fails to consistently protect tissue integrity and increases elastin fractures.

This study analyzes daily mobility patterns of manual wheelchair users with SCI using inertial sensors, revealing key metrics and consistent mobility behaviors across participants.

This paper introduces a compression framework for neural recording systems that reduces bandwidth demands while preserving spike detection accuracy.

This study shows that mechanical anisotropy in adipose tissues influences ovarian cancer cell migration through TGFβ-dependent mechanisms, independent of MMP activity.

This study examines how vibrotactile stimulation affects sensation and perception in the upper extremity, finding voltage correlates with intensity but not pleasantness, and location and movement impact perception.

This paper introduces a scalable fabrication platform for magnetic microrobots capable of precise intracorporeal navigation, validated in multiple models and demonstrating potential for precision medicine applications.

The paper develops methods to mechanically test and analyze nerve fiber deformation in the myenteric plexus of mouse colorectum under loading, providing tools for quantitative stretch ratio calculations.

This paper proposes a non-invasive microrobotic embryo transfer technique using magnetically actuated microcarriers to improve embryo delivery in assisted reproduction, enabling precise, image-guided delivery with minimal invasiveness.

The paper introduces VacTrap, a microfluidic device that isolates and spatially indexes single nuclei from mammalian cells with high efficiency, enabling single-cell multiomics applications.

This paper develops Apt-circRNAs for targeted antigen-presenting cell immunotherapy, showing efficacy in tumors and clinical trials.

The paper introduces A-PACE, an open-source toolkit for real-time electrochemical data analysis, improving peak detection, baseline fitting, and data processing efficiency.

The paper introduces T-PGI, a system for scarless, programmable genome integration, showing high-fidelity insertion with minimal structural variants.

This paper shows that periplasmic expression of GFP variants like sfGFP harms E. coli physiology, limiting their use as screening tools for recombinant protein production.

This study compares immersed boundary and arbitrary Lagrangian Eulerian methods for simulating cerebrovascular fluid-structure interactions, finding that ALE provides more accurate stress and strain measurements in smaller vessels.

This study shows that membrane geometry in nanopore electroporation affects electric field distribution and cargo transport, enabling controlled delivery patterns.

This study shows hyper-migratory CAR T cells reduce ovarian cancer metastasis and improve survival in mice.

This study validates a novel mechanical testing device for human cerebrovascular tissue, showing it can accurately measure viscoelastic properties and predict vessel wall behavior.

This study expresses carbonic anhydrase in Acinetobacter sp. Tol 5 to enhance CO2 conversion as a whole-cell biocatalyst, finding that periplasmic expression significantly improves activity.

This paper develops an AI model for heart murmur detection in phonocardiogram data using data augmentation and pre-trained models, achieving improved accuracy and faster evaluation.