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This paper demonstrates that 3D-printed scaffolds encapsulating red blood cell-derived extracellular vesicles can deliver sncRNAs effectively for CNS therapy.

This paper develops a single AAV vector system for liver-targeted gene knock-in therapy in mouse models of inherited liver diseases, achieving efficient therapeutic gene insertion without germline transmission.

The paper determines the interaction affinity and kinetics of the Aos1-Uba2 heterodimer during SUMO activation using qFRET and SPR, showing increased stability with SUMO and ATP binding.

This study couples microbial electrolysis cells with microbial fuel cells to produce green hydrogen using farm soil, wastewater, anaerobic sludge, and cow dung, achieving an average hydrogen production rate of 6.9 mL/day.

This paper introduces MAGiC, a novel superferromagnetic tracer for magnetic particle imaging, achieving higher resolution and signal intensity than existing tracers and demonstrating controllability as a microrobot.

This paper introduces ExoTFF, a hybrid EV isolation method that improves yield, purity, and scalability compared to conventional techniques.

The paper presents a low-cost spinning disk confocal microscopy system using a 25 megapixel CMOS camera and custom hardware, validated with biological samples.

This study proposes optimized dry EEG electrode tip geometries to reduce mechanical stress on the scalp under tilted conditions using finite element analysis.

The paper infers patient-specific metabolic fluxes in breast cancer using metabolic models and machine learning, showing they reflect molecular subtypes and heterogeneity but not clinical features.

This paper shows that anisotropic hydrogel degradation patterns enhance hMSC alignment, mechanotransduction, and osteogenic differentiation compared to uniform materials.

This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance angiogenesis in a pre-clinical model, suggesting their potential as a pro-angiogenic nanotherapeutic for bone repair.

The paper investigates whether extending step length or stepping over perturbations is more energy-efficient during uneven walking, finding a velocity-dependent threshold for each strategy.

This paper describes a novel biochemical pathway using a phosphatase to reverse the Leloir pathway in E. coli, enabling direct tagatose synthesis from glucose with high yield.

This paper develops a high-throughput qFRET method to determine protein interaction affinity without purification, revealing a two-enzyme co-recognition mechanism for SUMOylation substrates.

This study develops sweeping antibodies against IL-16, showing improved antigen clearance compared to conventional antibodies.

This paper introduces a new optical coherence elastography technique that maps Euler angles to improve breast cancer detection by accounting for tissue heterogeneity.

This paper evaluates contrast agents for in vivo fluorescence detection of circulating tumor cells, finding that while they show high uptake, they also label non-cancer cells, reducing specificity.

This study examines how shear stress and pressure affect pulmonary arterial endothelial cells in health and PAH, revealing divergent transcriptional responses across disease states and donor sex.

This paper introduces a microneedle-based capacitive biosensor for in situ detection of cardiac troponin I in interstitial fluid, showing high sensitivity and rapid results.

This study identifies peak anteroposterior heel slip acceleration as a predictor of lateral trunk flexion during unexpected slips, suggesting it as an early destabilizing mechanism.