Discover, rate, and discuss biology preprints.

This paper introduces a parallelized droplet vitrification technique for rapid, high-volume cryopreservation of rat hepatocytes, achieving higher yield and faster droplet generation with improved post-preservation viability.

This paper introduces ActinoMation, a tool for automating Streptomyces conjugation, achieving varying conjugation efficiencies across strains and plasmids.

This study shows that ApoE-tagged polymersomes retain more payload in injured nerves, while RVG-tagged polymersomes better penetrate nerves via intramuscular injection.

This study shows that heparin flexibility in the extracellular matrix affects VEGF mobility and bioactivity by influencing its interaction with VEGF receptor 2.

This study compares strain responses between surface- and voxel-based finite element head models, finding similar results except at interfacial boundaries where differences exceed 0.1.

This paper introduces a biomimetic nano-neoadjuvant platform that reprograms tumor microenvironments through immunomodulation, converting 'cold' tumors into immunogenic niches.

This study develops a duo-enzyme system for PET degradation by immobilizing PETase and MHETase on magnetic nanoparticles, achieving higher product release and enzyme stability.

This paper develops an AI model using fluorescein angiography images to detect pre-symptomatic diabetic retinopathy in Nile rats with high accuracy and identifies inflammation-related gene markers associated with early DR pathogenesis.

This study evaluates GelMA as a scaffold material for intestinal epithelial cells, finding it suitable for permeability, mechanical strength, and biocompatibility.

This study designs antibodies without prior information across eight targets, achieving high precision, sensitivity, and specificity, validated by Cryo-EM and comparable to commercial antibodies.

This study uses AI to humanize a murine antibody by grafting only essential paratopes, reducing immunogenicity while preserving efficacy and developability.

This study shows that co-delivering siRNA targeting IFNAR1 with RNA vaccines enhances antigen expression, immune cell infiltration, and antibody and T cell responses.

This study develops gold nanocages with a surface plasmon resonance peak at 1060 nm as contrast agents for OCT imaging, showing enhanced imaging contrast in phantoms and mouse tissues.

This study compares IMU and OMC methods for detecting gait events, finding OMC methods more accurate than sacrum-mounted IMUs.

The paper develops a microcosm fabrication platform for live microscopy of plant-soil systems, enabling controlled water content and observation of root-soil interactions.

This paper develops a multiplexed RT-LAMP test for detecting SARS-CoV-2, Influenza, and RSV in saliva with high accuracy using a machine-learning-enabled portable analyzer.

This paper introduces HYDRAC, a polymer-based platform for targeted protein degradation, demonstrating its effectiveness in degrading MYC and KRAS in vitro and in vivo.

This study shows that the maturity of the endothelial glycocalyx affects how charged nanoparticles and polymers interact with endothelial cells, influencing toxicity and binding.

CHIEF improves protein design by combining five models, achieving higher sequence recovery and lower perplexity, and successfully designing functional malate dehydrogenase.