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3D Chemotaxis Chip for Investigating Natural Killer Cell Migration Mechanisms

This paper develops a 3D chemotaxis chip to study NK cell migration mechanisms and finds protease-dependent migration and hyaluronic acid enhancement.

Dose dependence and neurovascular mechanisms of the fMRI response to pulsed photobiomodulation in humans

This study investigates the dose-dependent fMRI response to transcranial photobiomodulation in humans, showing non-local effects and parameter-dependent responses.

Integrin Activation Enhances Lesion-Specific Targeting of Monocyte-Mimetic Nanoparticles in Atherosclerosis

This study shows that activating integrins on monocyte-mimetic nanoparticles improves their targeting to atherosclerotic lesions without increasing toxicity.

Overexpression of a Gene That Modulates Cyclic-di-GMP Enhances Granulation in Mycobacterium smegmatis

This study shows that overexpressing dcpA in Mycobacterium smegmatis enhances granulation and granule stability, suggesting c-di-GMP modulation plays a key role in microbial aggregation.

Off-the-shelf NIR-I fluorophores as ready-to-use NIR-II probes: screening and in vivo validation

This paper identifies commercially available fluorophores that can be used as NIR-II probes, validated through in vivo imaging in mice.

A standardized toolkit for programmable protein secretion and surface display in Bacteroides thetaiotaomicron

This paper develops a standardized toolkit for predictable and tunable protein secretion and surface display in Bacteroides thetaiotaomicron by optimizing lipoprotein signal peptides.

Spatially precise neuron formation via hydrogel mediated modulation of the host astrocyte response

This paper develops a hydrogel-based system to reprogram astrocytes into neurons by delivering reprogramming factors and valproic acid, enhancing neural repair.

Neurofeedback Training on Motor Cancellation Enhances Peripheral but not Cortical Beta Band Oscillations

Cholesterol-Dependent Structure and Dynamics of Curved Lipid Vesicles Revealed by Dry MARTINI Simulations

This study uses Dry MARTINI simulations to investigate how cholesterol affects the structure and dynamics of curved lipid vesicles, finding increased membrane thickness and altered lipid behavior with higher cholesterol concentrations.

Lipid nanoparticle protein coronas arise through lipoprotein fusion rather than shell-like adsorption

This study shows lipid nanoparticles form protein coronas through lipoprotein fusion, not surface adsorption, using cryo-EM and simulations.

How representative are MNI152-derived montages for temporalinterference stimulation?

This study evaluates how representative MNI152-derived montages are for temporal interference stimulation across different brain targets and finds they underrepresent deep targets but overestimate coverage ratios.

Preclinical Evaluation of Molecular-Targeted Ultrasound Contrast Agents in a Rabbit Model

This study evaluates PSMA-targeted nanobubbles in a rabbit model to improve prostate cancer detection via ultrasound, showing enhanced tumor targeting and retention compared to conventional microbubbles.

A cuffed CRISPR guide RNA for microRNA activity-dependent genome editing

This paper introduces a cuffed guide RNA (cgRNA) that enables miRNA activity-dependent genome editing in human and mouse cells.

Bioactive Spermidine-Crosslinked DNA Hydrogel for rapid homeostasis and accelerated wound healing

This paper develops a DNA hydrogel that rapidly stops bleeding and promotes tissue regeneration in mice by combining hemostasis with bioactive properties.

Hydrogen-Driven Cell-Free Cofactor Regeneration Enables Stoichiometric Bioconversion of Pyruvate to Lactate

This study demonstrates hydrogen-driven cofactor regeneration for efficient pyruvate-to-lactate conversion using engineered enzymes.

Reduced risk of a next-generation recombinant viral vector engineered from a plant rhabdovirus genome

This study evaluates the risk of a recombinant plant rhabdovirus, MMV-GFP, compared to its wildtype MMV-WT, finding it less fit and posing no greater risk to crops or ecosystems.

Hydrogel formulation controls size-dependent accumulation of proteins and nanoparticles in PEG microparticles

This study shows how PEG hydrogel formulation affects the accumulation of proteins and nanoparticles, with larger molecules requiring more permissive formulations.

ContiDesigner: Bioprocess Intensification through System-Level Design of Continuous Fermentation Cascades

ContiDesigner is a tool for designing continuous fermentation cascades that identifies optimal operating conditions to maximize productivity.

Production of diverse retinal analogues in engineered Escherichia coli through promiscuous carotenoid cleavage by Blh

This paper demonstrates the biosynthesis of diverse retinal analogues in engineered E. coli using Blh, a carotenoid cleavage enzyme, through substrate promiscuity and structure-guided engineering.

Independent Mesh Realizations Introduce Percent-Level Variability in Temporal Interference Simulations

The paper quantifies variability in temporal interference simulations caused by non-deterministic mesh generation and shows that multi-run averaging reduces this noise.