Discover, rate, and discuss biology preprints.

The paper shows that nullomers in genomes arise from statistical properties rather than evolutionary pressures or lethal effects.

This study determines cryo-EM structures of the rice ammonium transporter OsAMT1;1 in wild-type and phosphomimetic states, revealing how phosphorylation induces inactivation by stabilizing a closed channel conformation.

This study identifies a stable charge-anchored binding mode for FAP ligands, providing a framework for designing effective radiopharmaceuticals.

This study shows that low CAR affinity improves T-cell synapse dynamics and activation by promoting receptor turnover and signaling.

This study shows that myosin I motor activities enhance lipid diffusion by converting low-speed lipids to high-speed and reducing confined and subdiffusive motion in actin-rich regions.

This study shows that Piezo1 signaling is influenced by force magnitude, mechanical history, and actin coupling under fluid shear, using a genetically encoded reporter in engineered cells.

This paper presents a hybrid quantum-classical framework for peptide folding, demonstrating a workflow that outperforms quantum refinement in structural accuracy for a short peptide.

PINPOINT provides non-destructive single-particle analysis of lipid nanoparticles and their mRNA cargo, revealing heterogeneity not detectable by bulk methods.

This study uses atom probe tomography to identify organic pigments in biogenic calcite, improving molecular identification and spatial distribution analysis at the nanoscale.

The paper demonstrates functional dynamics in the eukaryotic RNA exosome using NMR and EPR, showing subunit flexibility and conformational changes in the Exo9 complex.

The paper introduces HEAM, a dataset of human metalloproteins annotated for metal-binding sites and catalytic function, showing metalloenzymes are enriched in disease-related variants and pathways.

The paper develops a mean-field theory to show that linker stretching optimizes bonding entropy in sticker-spacer condensates by canceling length-dependent terms, supporting decoupling approximations.

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

The paper uses MD simulations and machine learning to compare residue-pair fluctuations in STING under different conditions, identifying distinct dynamic patterns.

This paper develops a computational framework to study quantum effects in cryptochrome's protein environment, showing it enhances FAD light absorption.

Comparing coarse-grained dynamics across resolutions, weighted by sampling uncertainty, yields phenotypic spaces linking E. coli run speed to CheB and showing paramecia experience narrows zebrafish variability.

This study investigates the sequence dependence of UV absorption in DNA using computational methods and finds that cytosine- and guanine-rich sequences absorb more UV than adenine-thymine-rich ones.

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

This study shows that buried ion-pairs in artificial proteins reshape folding pathways by introducing kinetic barriers that are overcome by hydrophobic collapse and core packing.

The paper introduces a geometrical framework for growth models that applies to different population structures and scales, showing how growth laws can vary based on component activation and space expansion.