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This paper uses single VLP lipid-mixing measurements and computational modeling to show that dengue virus fusion includes an off-pathway state that is slowly reversible.

This paper investigates the causal relationship between biological organization and Open-Ended Evolution using the Kauffman model and auto-catalytic sets.

This paper introduces a deep learning framework to classify intracellular calcium dynamics, achieving near 90% accuracy in distinguishing various dynamical states.

This study shows McsB phosphorylates CtsR's periphery arginine residues, altering its thermosensing and DNA binding properties.

This study determines the cryo-EM structure of stomatin, revealing its role in organizing functional membrane microdomains and identifying associated proteins involved in cell migration and vesicle trafficking.

This study shows PARP inhibitors reduce PARP1's DNA binding affinity by causing conformational changes independent of DNA, explaining similar cellular toxicities despite varying trapping potencies.

This study reveals the structural and functional role of Pex8 in peroxisomal cargo translocation by interacting with Pex5, facilitating receptor recycling.

This study uses microfluidic systems to investigate how different Hydra species respond to fluid flow, finding species-specific biomechanical responses such as alignment and attachment.

This study reports cryo-EM structures of TAP in multiple functional states, revealing how nucleotide-dependent conformational changes drive peptide transport and release.

This study investigates how the G256E HCM mutation affects myosin function by altering nucleotide handling, leading to prolonged relaxation and contributing to hypertrophic cardiomyopathy.

This paper investigates the molecular mechanisms of opalescence and liquid-liquid phase separation in mAb formulations and shows they are decoupled from aggregation.

The paper uses AlphaFold2 to predict structures of voltage-gated ion channel VSDs and pore regions, showing diverse conformations but noting discrepancies with experimental data.

This paper introduces C-Jump, a method to measure biomolecular interaction kinetics in solution without surface immobilization, demonstrating its accuracy for protein-protein and protein-small molecule interactions.

This paper describes VYD222, a broadly neutralizing antibody effective against SARS-CoV-2 variants, including Omicron, and explains its structural basis for resistance to viral escape.

This paper introduces a DNA barcoding method to simultaneously profile kinetic properties of protein variants at the single-molecule level, revealing kinetic diversity and structural subpopulations.

This study investigates the light-induced conformational changes in Drosophila cryptochrome using simulations and spectroscopy, revealing a blue-light induced state that may mediate signal transduction.

This paper introduces a method to reduce preferred orientation in cryo-EM samples using laser flash melting and revitrification, improving protein structure determination.

The paper designs a computational pipeline to identify small peptides that slow condensate ageing in TDP-43 and FUS by reducing condensate density through electrostatic interactions.

This paper introduces a fluid-derived lattice method to model bacterial colony growth, reducing artifacts from regular lattices and enabling efficient simulations of large populations.

This study introduces a non-equilibrium model to analyze protein allosteric behavior, showing that non-thermal fluctuations significantly impact allosteric communication.