Discover, rate, and discuss biology preprints.

The paper uses molecular simulations to study how phosphorylation by CK1δ affects TDP-43 condensates and aggregation, finding that phosphorylation patterns depend on sequence and charge rather than position.

This study examines how the D1/S264V mutation affects electron transfer and iron states in Photosystem II with different PsbA variants, revealing significant functional differences.

This paper introduces a new class of fluorophores with enhanced photostability, solubility, and tunable properties for advanced biological imaging applications.

This paper introduces near-zero photon imaging, a method that captures high-fidelity biological images at ultralow irradiance and high speed using AI.

This study uses molecular dynamics simulations to analyze LDLR-PCSK9 interactions and the effects of E498A and R499G PCSK9 variants on binding affinity and conformational dynamics.

This paper identifies a tethering mechanism by which Pin1 catalyzes proline cis-trans isomerization at a noncanonical site in the PPARγ AF-1 domain.

The paper introduces REDIFINE, a label-free method to characterize multicomponent biomolecular condensates using diffusion NMR, revealing insights into their biophysical properties and dynamics.

This study uses simulations to show that binder valency drives chromatin collapse while monomer valency determines reswelling, with two distinct mechanisms identified.

The paper introduces the IWQ model to explain temperature-dependent protein function and links body temperatures to water quantum transitions at protein interfaces.

This study identifies conserved allosteric hotspots in KRAS that mediate effector mimicry and allosteric modulation through molecular simulations and mutational analysis.

The paper measures cervical mucus viscoelasticity and sperm velocity in rhesus macaques, finding a strong negative correlation between mucus viscoelasticity and sperm velocity.

This study uses reconstituted actomyosin networks in liposomes to show how actin network connectivity and coupling strength control membrane deformation and bleb formation mechanisms.

This study uses smFRET to analyze conformational dynamics of LmrP, revealing antibiotic-dependent heterogeneity in its conformational landscape and interconversion kinetics.

This study shows that bacterial stiffness influences spatial organization and mechanical responses in the gut, suggesting mechanical properties can shape microbial localization and persistence.

This study uses molecular dynamics simulations to analyze how JAK2V617F and TYK2V678F mutations sustain JAK-STAT pathway activation through distinct conformational changes, providing insights for therapeutic targeting.

The paper decomposes predictive information in social dynamics using mutual prediction analysis in zebrafish dominance contests, revealing disruptions in autism-linked mutants.

This paper introduces cryoPROS, an AI method to address preferred orientation in cryo-EM, improving resolution without special experimental techniques.

The paper develops an adaptive optimization system for NMR CEST experiments to improve estimation of minor protein conformational states using Bayesian methods and MCMC.

This study compares the conformational equilibria of the human A2A adenosine receptor in lipid vesicles and aqueous solutions using 19F-NMR, revealing environment-dependent differences in agonist-bound states.

This study explains how power-law distributions of protein activity emerge from interaction-driven feedback mechanisms without intrinsic heterogeneity.