Discover, rate, and discuss biology preprints.

The paper shows potassium channels at the base and calcium channels at the tip of feather buds create a current loop essential for feather patterning and morphology.

The paper demonstrates that planarians can maintain long-term heritable gene silencing through a two-phase RNAi mechanism independent of canonical RdRPs.

This study shows Med12 and Med13 prevent dedifferentiation of intermediate neural progenitors and loss of neural stem cells in Drosophila by regulating gene expression through interactions with different mediator complex subsets.

This study creates a single-cell transcriptomic atlas of mouse oocyte development from growth to ovulation using a new platform and integrates transcriptomic and morphological data to identify temporal shifts in gene expression.

The paper introduces a whole-embryo spatial transcriptomics method and generates a comprehensive gene expression and chromatin accessibility atlas in zebrafish embryos.

This study examines how climate variables affect nestling development in two Patagonian bird populations, finding that climate impacts hatch weights but not growth rates or pre-fledging weights.

This study shows that constitutive β-Catenin activation in cortical hem progenitors disrupts CR cell identity by preventing the Tbr2+ stage.

The paper identifies a multipotent vascular niche in zebrafish that generates BBB and fenestrated endothelial cells, revealing Flt4's role in their segregation through signaling with Vegfr2.

This study shows ATF4 interacts with EcR to both activate and repress lipid metabolism genes in Drosophila fat body under homeostasis and stress conditions.

This study shows that ciliary cAMP levels regulate Shh signal interpretation during neuron differentiation by balancing Smo and GPR161 to control actin dynamics and polarisation.

The paper investigates Drosophila germ-band extension, revealing a two-state mechanism where the anterior tissue behaves fluid-like and the posterior behaves solid-like, enabling efficient reshaping.

Maternal immune activation disrupts placental vascular integrity through a COX2-dependent prostaglandin E2 pathway, compromising the placenta-blood barrier and relaying inflammatory signals to the fetus, identifying potential therapeutic targets for neuroprotection.

This study identifies an alternative epithelial patterning mechanism for vertebrate tooth complexity in squamates, showing that cusp formation does not rely on enamel knots but on a broad signaling field.

This study identifies the role of BMP antagonists in sustaining mandibular growth in zebrafish by regulating chondrocyte differentiation and cartilage organization.

This study shows that SLC25A1 in cardiomyocytes regulates differentiation, mitochondrial function, and cardiac development, linking mitochondrial citrate export to developmental gene programs.

This study shows that adipocyte-derived amino acid storage proteins are essential for maintaining germline stem cells in adult Drosophila females through TOR signaling regulation.

This paper introduces a high-throughput assay to measure Drosophila larval development with minute-scale precision and shows temperature affects developmental timing predictably.

This study shows that actomyosin organization in zebrafish cardiomyocytes drives cell shape changes during heart chamber curvature formation, influenced by both intrinsic and extrinsic factors.

This study identifies Nup107 as an essential regulator of Torso-mediated metamorphic transition in Drosophila by modulating EcR signaling and ecdysone biosynthesis.

This study develops 3D ovarian scaffolds using decellularized extracellular matrix and mechanically tuned hydrogels to improve in vitro ovarian models.