Discover, rate, and discuss biology preprints.

The paper uses CRISPR screens and Perturb-seq to identify gene programs and functional relationships in AD GWAS risk genes related to lipid and lysosomal pathways.

This paper describes a CRISPR-based gene drive targeting the doublesex gene in Culex mosquitoes to suppress populations through male-biased propagation and sterile intersexes.

This study identifies functional non-coding variants associated with orofacial cleft by combining GWAS, reporter assays, and stem cell modeling.

The paper investigates the genetic and environmental factors influencing the distribution of three chromosomal drive haplotypes in maize using GWAS and population data.

ClipperQTL identifies eGenes efficiently by reducing permutations needed for large datasets while maintaining performance comparable to FastQTL.

The paper describes DNA barcoding efforts during a mushroom foray, generating 803 ITS barcodes and identifying 18 novel species-level OTUs and 28 new distribution reports.

The paper identifies variants in PRPF8 and related genes associated with CAKUT, showing their role in splicing and ciliogenesis through functional experiments.

This study identifies sex-specific genetic and environmental contributions to retinal vascular traits through GWAS and interaction analyses, highlighting the need for sex-aware approaches in precision medicine.

The paper uses whole genome sequencing to show that human and dog-derived Strongyloides stercoralis are genetically distinct, with rare cross-infection events, suggesting the parasite originated in dogs and began infecting humans after domestication.

This paper identifies how outcome scaling and endogenous treatment effects create spurious gene-environment interactions and proposes a diagnostic to detect these artifacts.

The paper introduces IntAC, a CRISPR screening method for Drosophila cells that improves accuracy by suppressing early Cas9 activity, leading to a more comprehensive list of fitness genes.

This study identifies EPHA4 signaling dysregulation as a contributor to idiopathic scoliosis by linking it to locomotion defects and CPG network disruption in zebrafish.

The paper introduces a barcode-based method to track combinatorial genotypes in pooled experiments, enabling high-throughput genetic screening and analysis of complex genotype-phenotype relationships.

This study investigates the effect of a rare MYH11 variant in mice, finding it does not cause aortic disease but leads to cardiac hypertrophy and heart failure under pressure overload.

The paper develops a theoretical framework to study how conflicting selection pressures shape amino acid frequencies in plant self-incompatibility proteins, showing asymmetric effects on female and male proteins.

The paper updates the wRBP1.0 compendium of C. elegans RNA-binding proteins to 928 proteins, cataloging their expression and developmental phenotypes.

The paper investigates telomere length inheritance in budding yeast, showing that long telomeres can persist through multiple generations without mutations.

This study examines genetic diversity and structure of wild and farmed Saccharina latissima populations in Europe to assess gene flow risks and traceability.

This study identifies genetic modifiers of maneb-induced dopaminergic neurodegeneration in Drosophila using genome-wide association analysis and validates candidate genes involved in Wnt signaling.

The paper develops an algorithm to accurately assign breed origin to alleles in crossbred dairy cattle, achieving high accuracy in simulated breeding programs.