Discover, rate, and discuss biology preprints.

The paper identifies departures from polygenic architecture in the tails of complex traits, showing rare alleles are more prevalent and impactful in extreme trait values.

The paper develops a convex optimization framework for mate allocation in polyploid populations to control inbreeding and predict heterosis, showing improved genetic gain with pedigree kinship.

This study examines how dietary chitin affects chitinase activity, gene expression, and gut microbial composition in Atlantic salmon.

This study shows that Hill-Robertson interference in highly selfing species biases the inference of mutation fitness effects, leading to misestimation of selection coefficients and adaptive substitution rates.

This study shows that increased centromere-proximal crossovers cause meiotic nondisjunction and biorientation in S. pombe, supporting the entanglement model and highlighting mechanisms of aneuploidy.

This paper benchmarks genotyping and imputation methods for degraded DNA in forensic applications across diverse populations, finding that ATLAS outperforms conventional tools and that reference panel diversity improves accuracy.

The paper compares gene expression between chronic rhinosinusitis with and without nasal polyposis, finding differences in clinical scores and gene recurrence rates.

This study shows HSP90 buffers BRCA1 mutations, reducing their clinical severity and contributing to PARP inhibitor resistance in cancer cells.

This study identifies the cGMP-dependent pathway and a GPCR kinase as essential for light avoidance in Pristionchus pacificus, revealing similarities and differences in phototransduction compared to C. elegans.

This study examines how lungworm infection affects miRNA and mRNA expression in cane toads, finding upregulated miRNAs linked to immune response pathways and minimal mRNA changes.

This paper introduces env-MR-MEGA, a meta-regression model that adjusts for environmental and ancestral heterogeneity in GWAS meta-analysis, improving association power.

This study uses Drosophila to model PEX gene variants associated with different severities of peroxisomal biogenesis disorders, showing phenotypic variation based on mutation type.

The paper provides a practical guide for analyzing categorical data in biological experiments using logistic regression and the Cochran-Mantel-Haenszel tests, with examples from Caenorhabditis elegans research.

The paper identifies a self-restraining sex chromosome driver in D. melanogaster that prevents population extinction by asymmetric segregation during meiosis.

The paper constructs a sheep developmental gene expression atlas and identifies key genes associated with economically important traits by analyzing gene expression across developmental stages.

This paper introduces peCHYRON, a DNA recorder that sequentially records cellular events in mammalian cells using prime editing, enabling durable, high-information, and temporally resolved molecular recording.

The paper identifies RNAi loss-of-function mutations in Cryptococcus neoformans and shows they can lead to hypermutation when combined with transposon burdens.

The paper investigates how moderate temperature stress affects germline apoptosis and cytoplasmic streaming in C. elegans, identifying LIN-35 and the DREAM complex as key regulators.

The paper compares the distribution of fitness effects of new amino acid changing mutations between dogs and wolves to assess the impact of domestication on selective pressures.

This paper develops a simple, environmentally friendly DNA extraction and PCR-RFLP method for genotyping the MS4 gene in Cryptomeria japonica, suitable for field use.