Discover, rate, and discuss biology preprints.

This paper constructs a fine-scale genetic map of the Japanese population using whole-genome sequencing data, identifies recombination hotspots, and shows improved haplotype phasing and imputation accuracy.

The paper investigates changes in TP53 gene, telomere length, and mitochondrial DNA in BPH patients, finding prolonged telomeres and mtDNA amount changes, but no TP53 mutations linked to BPH.

The paper identifies a new invasive soft coral species, Xenia umbellata, in southwest Puerto Rico using genetic analysis and highlights its ecological impact.

A spatial 3D genomics approach was developed to analyze hierarchical chromatin conformation in situ in tissue sections, revealing organ-specific and conserved chromatin interactions.

This study shows that CRWN nuclear lamina components in Arabidopsis are essential for maintaining H3K27me3 chromatin marks, which are critical for normal gametophyte development and seed viability.

The paper compares genetic and oral histories of four Indian populations, finding genetic similarity to other Indian groups but no evidence of additional non-local genetic sources.

The paper evaluates maternal effect lethality and genetic background effects in Naa10 knockout mice, finding no replication of maternal effect lethality but some embryonic lethality in specific genetic backgrounds.

The paper investigates how genetic variants in PNPLA3, MBOAT7, and TM6SF2 affect mitochondrial function in MASLD, showing that restoring these proteins improves mitochondrial bioenergetics and that circulating respirometry reflects hepatic mitochondrial status.

The paper analyzes genetic variation in 2,021 cowpea accessions to identify population structure and map the genetic basis of seed coat pigmentation traits.

The paper investigates how two STAT5B SH2 domain variants affect mammary tissue development and lactation by altering enhancer recognition and gene regulation in mice.

The paper tests a schizophrenia-associated variant near TSNARE1 and ADGRB1 for functional effects, showing allele-specific transcriptional differences and pathway enrichment in synaptic processes.

This paper introduces GUIDE, a method to identify latent genetic factors from GWAS data, revealing biological pathways and environmental influences in complex traits.

This study shows that transcription factor condensates cluster target genes and enhance their expression in response to methionine starvation in yeast.

This study identifies TabHLH27-A1 as a key gene influencing root growth and drought tolerance in wheat, improving water use efficiency through genetic manipulation.

This study uses deep learning on UK Biobank DXA data to analyze the genetic architecture of pelvic morphology, finding heritable traits and genetic correlations related to the obstetrical dilemma.

The paper identifies miR214 and dnm3os as regulators of sex determination in zebrafish, showing miR214 promotes female development through gsdf and dnm3os has a maternal effect on sex determination.

The paper identifies rs7132908 as a causal variant in the chr12q13 obesity locus, showing it affects FAIM2 expression and neurodevelopment through cis-regulatory mechanisms.

This study develops a zebrafish injury model to study heterotopic ossification, identifies differentially regulated genes, and shows that Kcnk5b and Il11ra influence bone formation after injury.

The paper describes the development of a course on genetics, ethics, and society designed by trainees to address the lack of ethics training in scientific education.

The paper investigates mutation mechanisms during homologous recombination in yeast, showing that mismatch repair suppresses quasipalindrome and frameshift mutations during double-strand break repair.