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FlexRV improves gene discovery for complex traits by modeling nonlinear relationships between variant annotations and phenotypes, outperforming existing methods in association detection and replication.

The paper investigates how hybridization affects gene expression in brain tissues by identifying cell type-specific regulatory variation in interspecies fish hybrids.

This study shows that disrupting the insulin signaling pathway in male C. elegans significantly increases lifespan and improves reproductive health late in life.

This paper shows that deleting the mbk-1 gene in C. elegans impairs locomotion but not chemosensory function or learning, and humanized replacement restores normal movement.

This paper identifies a Y-linked duplication of the anti-Mullerian hormone gene (amhy) as the primary sex determination gene in threespine stickleback, showing its necessity and sufficiency for male sex determination.

The paper investigates how modifying Cas9 regulatory elements affects gene drive performance in Drosophila, finding that promoter truncation reduces resistance allele formation but decreases germline cutting efficiency.

This study analyzes genomic data from 52 individuals across the central Southern Cone to trace genetic ancestry and movements during the Middle to Late Holocene.

The paper identifies intron retention quantitative trait loci (irQTLs) in human tissues and shows their association with GWAS traits and eQTLs, revealing shared genetic regulation and potential NMD effects.

This study tracks daily and weekly urobiome fluctuations in postmenopausal women without UTI history, finding stable community structures and potential colonization resistance mechanisms.

The paper evaluates genomic prediction for general combining ability in canola hybrids using different cross-validation strategies and finds varying predictive abilities across traits.

This study identifies ADAMTSL4 as a causative gene for ectopia lentis et pupillae, showing its role in regulating extracellular matrix and cell migration through COL8A1.

The paper examines trends in yield phenotypic plasticity and heritability in winter wheat cultivars over time, finding increased plasticity and decreased heritability, with genomic regions for yield varying by environment.

The paper investigates how trans-eQTL hotspots contribute to phenotypic heterosis in maize by regulating non-additive gene expression through transcription factors.

This paper introduces Bayesian fine-mapping methods adapted for related individuals, showing improved accuracy in pig data compared to existing tools.

The paper integrates ancient genomic and phenotypic data to analyze stature in prehistoric Europeans, finding that lactase persistence alleles positively affect stature in ancient populations but not in modern ones.

The paper investigates how Neanderthal-derived variants in an enhancer region affect craniofacial development and disease risk by testing their regulatory activity in zebrafish.

This study shows that strong GAL4 expression in Drosophila fat body causes physiological defects, including reduced lipid stores and infection resistance, and identifies factors that influence these effects.

The paper uses bulk segregant analysis to identify genomic regions linked to imidacloprid resistance in Colorado potato beetles and finds that RNAi reduces resistance, challenging its use for validation.

This paper highlights how confounding factors lead to misinterpretation in genetic studies of human behavior and socioeconomic outcomes by reanalyzing two examples.