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This study shows plasmids can form chromatin structures in mammalian cells and uses plasmid Fiber-seq to map these structures and their functional consequences.

The paper examines mitonuclear discordance in Latin American admixed populations, finding lower MND in affected individuals, especially for OXPHOS and high-mt genes, suggesting links to disease.

The paper identifies 612 human inversion variants using ultra-long read sequencing and develops a bioinformatic tool to genotype them across 54 individuals.

This study identifies genomic loci associated with agronomic and grain traits in tef, revealing novel marker-trait associations and retrotransposon effects on grain color and size.

The paper shows that targeted breeding strategies in rhesus macaques reduced SIV-refractory MHC haplotypes without decreasing genetic diversity.

The paper analyzes 32 Arthrobacter phages in Cluster AZ, revealing genomic diversity and host range correlations.

The paper examines somatic mutations in neurons across tau pathologic states in Alzheimer's disease and finds increased mutation burden and specific mutational signatures in AD neurons.

The paper examines sex biases in the human brain transcriptome across development and adulthood, finding that many sex differences originate in the prenatal period and persist into adulthood.

The paper presents and compares whole-genome assemblies of two lamprey species, suggesting they form a species complex with distinct ecotypes.

The paper introduces ICE, a framework for detecting senescent cells using weak single-cell markers, improving detection accuracy from 56% to 98% in pancreatic cells.

The paper introduces CiBER-seq, a CRISPRi platform that improves the sensitivity and scope of genome-wide screens by normalizing expression reporters against control promoters, and validates its ability to capture post-transcriptional and post-translational regulation.

The paper shows that aligning RNA-seq data to strain-specific genomes increases the number of differentially expressed genes and exons detected when comparing C57BL/6J and DBA/2J mice.

The paper examines the transcriptomic response in honey bee mushroom bodies infected with DWV, finding immune gene upregulation and lncRNA-driven gene regulatory networks, with no correlation between DWV load and cognitive function.

The paper uses pangenome graph analysis of 19 spinach downy mildew isolates to study the evolution of resistance-breaking traits and identifies effector candidates associated with resistance breakdown.

The paper identifies an endogenous retroviral element that uses an upstream enhancer for somatic expression and mobility in Drosophila intestine.

The paper evaluates regional heritability mapping methods to identify QTLs in Soay sheep, finding that some methods detect new trait-associated regions not found by GWAS.

GBRAP provides a database and tool for analyzing genomic diversity across all domains of life by offering curated genome statistics and visualization capabilities.

The paper integrates somatic mutations and gene expression in OSCC-GB to identify SON gene variants linked to enhanced stemness and disease progression under DNA damage response.

The paper presents a high-quality marine Threespine Stickleback genome assembly from Rabbit Slough, which includes regions deleted in freshwater populations and provides a better reference for evolutionary studies.

This paper identifies a distinct Type IV Secretion System (T4SS) in Patescibacteria, showing it evolved from monoderm bacteria via horizontal gene transfer and is adapted for non-conjugative functions.