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This study examines antibody responses to Shigella in Bangladeshi children, finding that younger children have less effective functional antibody responses against OSP and proteins, correlating with disease severity.

This study shows histotripsy induces vascular remodeling in tumors, improving perfusion and drug delivery, and enhances immune cell infiltration.

This study identifies NLRP3 inflammasome signaling as critical for organizing hepatic granulomas and promoting protective immunity against Leishmania infantum.

The paper shows that sepsis reprograms monocytes into a pro-inflammatory state and shifts their lineage toward neutrophil-like cells, increasing lung injury risk in survivors.

This study identifies distinct transcriptional states of T cells in draining lymph nodes after influenza vaccination in individuals with African or Asian ancestry using scRNA-seq.

This study shows that IL-10 signaling deficiency impairs FMT engraftment and C. difficile resolution, and that IL-10 immunotherapy can restore FMT efficacy in mice.

This study identifies three small molecule inhibitors that reduce macrophage survival and viability, showing therapeutic potential in models of inflammation and cancer.

This paper introduces a modular SrtA-based toolkit to track T-cell interactions with different antigen-presenting cells in vivo, showing that ILC3s and conventional dendritic cells activate CD4+ T cells similarly.

This study creates a single-cell immune repertoire atlas in IBD patients, revealing coordinated immune states and identifying potential therapeutic targets.

Epidermal NLRP1, PYCARD and CASP4 versus dermal GSDMD polarity in systemic sclerosis skin is reproduced by same-donor cell-class pseudobulk for PYCARD and GSDMD, but rarely NLRP1.

The paper identifies hormone-specific microRNA signatures in vaginal epithelial cells and their effects on mRNA targets related to cell adhesion, immune response, and pathogen susceptibility.

The paper develops monoclonal antibodies for detecting inflammation biomarkers in common marmosets using recombinant proteins and validates their performance in various immunoassays.

The paper uses spatial transcriptomics to identify immune and epithelial changes in oral premalignant lesions that precede cancer, revealing potential biomarkers and mechanisms for early interception.

This study uses single-cell RNA sequencing and spatial profiling to show fibroblasts influence neutrophil inflammation in UC, with 5β1 targeting reducing inflammatory responses.

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

This study shows that sympathetic neurons regulate T cell and B cell responses to Streptococcus pneumoniae infection, enhancing IgG production and bacterial clearance.

This study shows that KMT2D promotes effector molecule release in NK cells by regulating H3K4me1 and RAB3D levels, affecting cytotoxicity and cytokine production.