Discover, rate, and discuss biology preprints.

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

The paper characterizes the taxonomic composition and predicted functional potential of a commercial microbiome-based fertilizer additive and agricultural soils in Paraguay, revealing functional overlap with plant-associated microbiomes and conserved functional profiles across soil types.

This study shows L-cysteine inhibits Vibrio parahaemolyticus growth by increasing ROS levels, disrupting membrane integrity, and reducing virulence.

The paper compares NA biosensors with Orbitrap MS for tracking naphthenic acid remediation in mesocosms and wetlands, finding biosensors track NAFC declines and show distinct response profiles.

This study identifies and characterizes a SARS-CoV-2 Mpro G23 deletion mutant resistant to ensitrelvir but not to nirmatrelvir or remdesivir.

This study characterizes prokaryotic communities across vertical layers of beech forest floors, finding that decomposition stage drives stratification and site conditions influence boundary layers.

This study shows that arcA and fnr in Salmonella Typhimurium protect against bile stress by reducing ROS and maintaining membrane integrity through nitrate metabolism.

This study examines how mucins affect phage infection and biofilm formation in Yersinia enterocolitica, showing enhanced phage replication and bacterial survival with mucin exposure.

This paper evaluates predictive methods for rhamnolipid production in Pseudomonas aeruginosa mutants using quantitative LC/MS analysis, revealing high misprediction rates in traditional phenotypic assays.

This study identifies novel DacA interactors in Streptococcus mutans, revealing a functional link between DacA and SMU_723, a putative calcium transporter, in c-di-AMP signaling and calcium homeostasis.

This paper compares fungal secretomes and enzyme cocktails under different fermentation modes to optimize lignocellulosic saccharification of flax shives.

This study identifies four T3SS-secreted effectors in V. campbellii that exhibit cytotoxicity in eukaryotic cells, highlighting conserved T3SS structure but variable effector repertoires across the Harveyi clade.

This study identifies a CTCF-binding element in the wtAAV2 genome that enhances rAAV transgene expression by shaping chromatin structure, offering a strategy to improve gene therapy vectors.

The paper reports the genome of Candidatus Argioplasma dusa, a spider symbiont, and finds it has a small genome with limited biosynthetic capabilities, suggesting an endosymbiotic lifestyle.

This study shows S. aureus persists in musculoskeletal tissues despite antibiotic therapy, with residual bacteria capable of causing relapse.

The paper compares microbial communities on coastal concrete and drainage pipes, finding distinct diversity and functional roles, but overall net deterioration dominates over healing.

The paper shows Pseudomonas aeruginosa uses a CRISPR-Cas system to silence a proline-codon toxin that stops phage growth, revealing a defense mechanism against anti-CRISPR phages.

This study determines the structural basis of antigen recognition by two mAbs targeting PfCSP, revealing conserved and distinct binding modes and their implications for antibody function.