Discover, rate, and discuss biology preprints.

This paper introduces a deformation in probability estimation to a reinforcement learning model, linking it to anxious-depression symptoms in psychiatric disorders.

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

This paper develops a small molecule that disaggregates tau fibrils and oligomers, reduces pathology, and preserves function in a tauopathy mouse model.

The paper investigates how VPA exposure and OT neuron stimulation affect microglia in the PVH and finds that OT neuron activation can reverse some microglial gene downregulation.

The paper uses electrical stimulation to map directional connectivity in human visual cortex, revealing an asymmetric architecture of interareal influence.

This study identifies PPTg glutamatergic neurons as critical modulators of PPI in mice, showing their role in shaping startle responses through time-dependent effects on PnC neurons.

The paper presents the complete connectome of the Drosophila male central nervous system and compares it to the female connectome, identifying sex-specific and dimorphic neuronal types.

This study identifies VDAC1 as a regulator of DJ-1's mitochondrial matrix localization, showing its role in maintaining mitochondrial homeostasis and neuronal survival under stress.

The paper analyzes resting-state fMRI-electrogastrogram data to reveal the time-averaged and time-varying structure of the gastric network, showing it is dynamically reconfiguring and coordinated by multisensory integration.

This study shows MHC class II upregulation in dopaminergic neurons due to maternal immune activation leads to reduced GABAergic synapses and behavioral deficits.

The paper shows that core circadian clock genes control both circadian and circatidal rhythms in Parhyale hawaiensis, with distinct transcriptional wiring in circatidal neurons.

The paper identifies functionally distinct subtypes within Grpr+ neurons in the dorsal horn that mediate itch and mechanical allodynia, demonstrating the utility of genomic enhancer-based strategies for modality-specific targeting.

The paper maps serotonin autoreceptor expression in Drosophila using single-cell sequencing and genetic labeling, identifying 5-HT2A and 5-HT7 in serotonergic neurons.

This paper explores privacy-preserving visualization techniques for brain functional connectivity using differential privacy to protect participant data while maintaining visual utility.

This paper shows that prioritization in working memory reduces interference by transforming the unprioritized item into an 'unprioritized' state, linked to low-beta frequency oscillations.

This study assesses the test-retest reliability of motor evoked potentials (MEPs) in lower-limb muscles, finding that reliability varies by muscle, stimulation intensity, and quantification method.

This study shows ketamine broadens neural spatial tuning and impairs spatial working memory in healthy humans, linking NMDAR antagonism to cortical microcircuit disruptions.

This study presents a one-step protocol to differentiate hiPSCs into functional astrocytes, enabling co-culture with neurons to support network development.