Discover, rate, and discuss biology preprints.

This study shows that mitochondrial copper deficiency drives MASLD by causing ferroptosis, senescence, and fibrosis, and that restoring copper homeostasis can alleviate disease.

This paper develops a deep learning method to virtually stain 3D microCT lung tissue, mimicking histological stains and enabling 3D pathology analysis.

This study identifies that adventitial progenitor cells differentiate into elastogenic SMC-like cells, contributing to false lumen remodeling through de novo elastic fiber formation following aortic dissection.

This study evaluates the impact of a 3D pathology workflow on DNA, RNA, and protein integrity, showing minimal effect on amplifiability and transcriptomic profiles.

This paper introduces PICASSO, a framework that makes pathology foundation models interpretable and controllable by decomposing embeddings into human-interpretable visual concepts, enabling new biological insights and downstream applications.

The paper uses proteomics to show increased ECM remodeling and complement activation in cardiac ATTR amyloidosis.

This study identifies DGR-1 as a transcription factor that switches from lytic to biotrophic effector production in plant-parasitic nematodes, working antagonistically with SUGR-1 to regulate effector expression during infection.

This study integrates multi-omics data to identify c-Jun as a key driver of tubular injury and fibrosis in diabetic nephropathy.

This paper identifies AvrStb6 as a fungal effector that protects Zymoseptoria tritici from antagonistic wheat-associated bacteria by associating with the fungal cell wall.

This study evaluates the efficacy of INVA8001, a chymase inhibitor, in reducing liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice with PSC-like features.

The paper uses AI to analyze pancreatic islet composition in type 1 diabetes, finding age, sex, and region-dependent changes and beta-cell loss with reciprocal cell expansion.

This study shows that loss of asgr1a in zebrafish leads to excess dietary cholesterol excretion rather than hepatic accumulation, suggesting a role for ASGR1 in cholesterol metabolism.

This study examines how Hofbauer cells respond to HIV and CMV at different gestational stages, revealing distinct transcriptional and functional immune responses that evolve during pregnancy.

This paper introduces a method using PBCT to create 3D virtual histology of FFPE prostate biopsies, enabling nondestructive 3D analysis of tumor architecture and distinguishing Gleason patterns.

The paper identifies MTAP deficiency as a biomarker in lung neuroendocrine neoplasms, distinguishing carcinoids from SCLC and LCNEC, and shows it is not caused by 9p21 deletion or promoter hypermethylation.

This study uses multiomic analysis to identify IFN signaling as a key driver in Hailey-Hailey disease and shows that ruxolitinib treatment reduces inflammation and improves patient outcomes.

This study demonstrates the antimalarial and immunomodulatory effects of Himalayan Buransh in vitro, in vivo, and in silico, showing potential as an adjunct therapy for drug-resistant malaria.

This study uses spatial transcriptomics to compare gene expression in ovarian clear cell carcinoma and adjacent endometriosis across UK and Japanese patients, finding distinct transcriptional patterns by tissue compartment rather than geographic origin.

The paper evaluates mRNA transcript abundance of IGF1, MKI67, TGFB1, and ACTA2 in equine endometrosis samples and links them to histopathological features.