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This study identifies DNA damage-driven senescence and ZBP1-cGAS-STING signaling as conserved mechanisms linking cardiovascular-kidney-metabolic comorbidities to HFpEF.

This study develops an age- and sex-structured model to estimate Chikungunya transmission and optimize control strategies, identifying asymptomatic males aged 15-59 as the core transmission group and highlighting mosquito suppression as the most effective intervention.

This study characterizes a chronic UV-induced photoaging mouse model, showing reduced HA content, altered DNA repair, and increased adipogenesis over eight weeks.

The paper investigates the potential threat of Cassava witches' broom disease fungus to cacao trees in French Guiana through cross-pathogenicity trials and PCR diagnostics.

This paper introduces a rapid H-ORO staining protocol for zebrafish frozen sections that preserves tissue integrity and reduces artifacts compared to traditional methods.

This paper introduces MambaWSI, a state space model for whole slide image classification that extracts multi-scale local and global features, achieving better performance than existing methods.

This study identifies the sPRR/AT1R/Yap/Taz axis in macrophages as a driver of renal fibrosis in UUO by promoting M2 polarization and fibrotic gene expression.

This study uses Drosophila midgut to investigate SARS-CoV-2-induced gastrointestinal pathogenesis, finding disrupted epithelial architecture, altered lipid homeostasis, and partial mitigation by Plitidepsin.

This study identifies MPO as a post-translational inhibitor of CatK, linking acute inflammation to sustained fibrosis through impaired collagen degradation.

This study shows that METTL14-dependent m6A modification prevents myocarditis and dilated cardiomyopathy by restraining IFN signaling and necroptosis in cardiomyocytes.

This study analyzes the causes of death in stranded cetaceans in the Canary Islands from 2013-2018, finding that natural causes accounted for 73.6% of deaths, anthropogenic causes for 12.9%, and 13.4% were undetermined.

Sequenced HBV from wild Amazonian primates in a deforested, densely settled region matched human genotypes A and D, while pristine-forest monkeys were all negative, consistent with human-to-primate spillover.

The paper develops a Fiji plugin to measure alveolar chord length and septal thickness in BPD research, validated across animal models and human lungs.

This study compares platelet and leukocyte transcriptomes in MPN patients, finding platelets better capture myelofibrosis signatures and provide more accurate diagnosis.

This study develops fluorescently labelled fungal pathogens to study their infection biology and interactions in pyrethrum plants.

The paper uses a deep learning pipeline to analyze placental histology and identifies cellular and structural changes across different lesion types.

This study compares parasite biomass in spleen-intact and splenectomized patients with acute P. vivax malaria, finding that 89% of total-body parasite biomass is splenic.

This study identifies p73 isoform imbalance as a key driver of DLBCL survival and chemoresistance, with {Delta}Np73 promoting resistance and TAp73 acting as a tumor suppressor.

This study shows that KRAS mutations impair lymphatic valve development by upregulating MMPs, which degrade the valve ECM core.