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This paper introduces VQ-MIL, a weakly supervised vector quantization method for WSI classification, achieving state-of-the-art results on benchmark datasets.

This study shows melatonin alleviates lysosomal damage in diabetic kidney disease by upregulating TFEB and the miR-205-5p-LRP-1 pathway, improving autophagy and oxidative stress.

This study uses spatial transcriptomics to compare gene expression in intima and media of human coronary arteries, revealing dedifferentiated SMCs in DIT that differ from proinflammatory SMCs in atherosclerotic lesions.

This study evaluates the immunopharmacological efficacy of Leishmania donovani overexpressing Ld_ζ1domain as a vaccine candidate against visceral leishmaniasis, showing reduced parasite burden and enhanced immune response.

This paper introduces a protocol for 3D multiplexed immunohistochemistry using Opal-TSA conjugated fluorescent dyes to enhance imaging of pulmonary TB lesions in mouse tissues.

This paper develops a RPA-DETECTR assay for rapid, sensitive, and specific detection of Foc TR4, outperforming PCR and qPCR in speed and sensitivity.

This study shows that pathological tau isoforms in retinal ganglion cells (RGCs) are linked to RGC degeneration in Alzheimer's disease, with significant correlations between tau levels and disease severity.

This study characterizes SVNV proteins through sequence analysis of field strains and compares their localization in plant and insect cells.

This study shows that higher parasite burden in vertebrate hosts leads to shorter extrinsic incubation periods in mosquitoes, but not increased transmissible stages.

This study shows that a diet enriched with deuterium-reinforced polyunsaturated fatty acids (D-PUFA) prevents muscle atrophy and weakness in STZ-induced diabetic mice.

This study re-establishes the golden Syrian hamster as an MCF model and identifies T cells and macrophages as key infected cells, with broader viral tropism including endothelial cells and epithelia.

This study shows that loss of LCAD protects against acute kidney injury by reducing oxidative stress and enhancing peroxisomal fatty acid oxidation.

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

This study investigates the limited effectiveness of enzyme replacement therapy (ERT) in advanced Fabry disease cardiomyopathy, identifying myocardial fibrosis, inflammation, and reduced mannose-6-phosphate receptors as barriers to therapy.

The paper examines how anxiety levels affect risk and loss aversion in decision-making tasks and their relation to pandemic-related behaviors.

This study shows that an oro-nasal fistula in mice causes microbiome dysbiosis, which hinders healing, but delivering Lactococcus lactis subsp. cremoris promotes healing and restores microbial balance.

This study analyzes longitudinal electronic health records to identify comorbidity patterns influenced by COVID-19 and their biological mechanisms through protein-protein interaction networks.

This paper investigates the localization of factor XI in human deep vein thrombus and evaluates the effects of FXIa and FXa inhibitors on venous thrombus formation and hemostasis in rabbits.

This study examines sex differences in GLA protein processing and its impact on disease severity in Fabry disease, finding that females have higher GLA activity and mature protein levels associated with less severe outcomes.

This study shows that deleting LRP6 in SMA-expressing cells prevents lung inflammation and fibrosis caused by bleomycin.