Sunder Sims‐Lucas

Novel high-resolution ion mobility mass spectrometry for site-specific quantification of the sirtuin-5 regulated kidney succinylome

This study uses PAMAF mode HRIM-MS to quantify succinylation sites in mouse kidney, showing Sirt5 regulates succinylation of mitochondrial proteins involved in metabolism.

Mitochondrial organization in the developing proximal tubule is controlled by LRRK2

This study shows that mitochondrial redistribution in developing proximal tubule cells depends on fluid flow and LRRK2 activity, which is regulated by shear stress.

Loss of long-chain acyl-CoA dehydrogenase protects against acute kidney injury

This study shows that loss of LCAD protects against acute kidney injury by reducing oxidative stress and enhancing peroxisomal fatty acid oxidation.

Substantial Downregulation of Mitochondrial and Peroxisomal Proteins during Acute Kidney Injury revealed by Data-Independent Acquisition Proteomics