Discover, rate, and discuss biology preprints.

This study identifies inducible bronchus-associated lymphoid tissue in SARS-CoV-2 infected rhesus macaques, suggesting local immunity plays a role in infection.

This study identifies Hsp25/27 as a key mediator of mucosal healing by integrating host and microbial signals in intestinal epithelial cells following inflammatory injury.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This study shows that exosomes from splenic ischemic preconditioning reduce renal ischemia-reperfusion injury by decreasing inflammation and apoptosis.

The paper shows E6AP is critical for HPV E6 regulation of epithelial homeostasis, with its loss impairing keratinocyte differentiation and YAP activation.

This study compares the inflammatory, neuropathic, and structural pathways in prurigo nodularis (PN) to atopic dermatitis (AD), finding increased NGF and ECM remodeling in PN.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.

This study establishes a mouse model of post-traumatic joint injury and identifies Gli1+ mesenchymal progenitors as key contributors to arthrofibrosis and heterotopic ossification.

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

The paper identifies 19 new quantitative trait loci (QTL) associated with susceptibility to Schistosoma mansoni infection in a murine backcross cohort, with two QTLs linked to granuloma number, liver lesion grade, and IgM levels.

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

This study identifies myostatin upregulation in paravertebral muscle cells as a driver of oxidative stress and apoptosis, contributing to idiopathic scoliosis development.

This study shows that abductor injury in mice leads to hip osteoarthritis, with cartilage degeneration and collagen loss, suggesting a link between muscle pathology and OA development.

The paper examines the glycome of synovial mast cells in normal and diseased tissues, finding increased mast cell numbers in arthritis and linking MGAT5 activity to mast cell and endothelial cell interactions.

This study investigates how DWV spreads among honey bees through social behaviors and vector interactions, showing host-to-host and host-to-vector transmission can sustain the pathogen in a population.

This paper develops an imaging flow cytometry method to quantify temperature-induced platelet shape change, showing a consistent transition from fusiform to circular shapes in mouse and human platelets.

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.