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This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

This study compares high- and low-level deep learning approaches for microsatellite instability prediction using TCGA data, finding the high-level approach superior and identifying key morphological features.

This study shows dietary αKG inhibits SARS-CoV-2 infection and reduces lung inflammation and thrombosis in animals, restoring oxygen saturation.

This study develops a mathematical model of the incompatible insect technique (IIT) with Wolbachia to control malaria, showing it can effectively reduce disease transmission even with contamination.

This study compares biochemical differences between prions isolated from the brain and lymph node of white-tailed deer with chronic wasting disease.

This paper introduces a new histologic grading system for murine knee osteoarthritis that scores the entire joint, showing high reproducibility and sensitivity for detecting OA progression.

This paper presents a deep learning system for prostate cancer detection in whole slide images and uses occlusion-based explainability to identify key histomorphological features used for classification.

This paper develops protocols for three-dimensional STED and confocal imaging of FFPE kidney tissue, achieving similar staining and image quality as previous methods.

This study shows that knocking out TSPO in Alzheimer's disease models delays disease onset and reduces amyloid, Tau, astrocytosis, and behavioral issues.

This study uses single cell and spatial transcriptomics to identify microglia-plasma cell interactions in the mouse brain during chronic T. brucei infection.

This study shows that increasing MBOAT7 expression in mice with NASH does not significantly improve liver histology, likely due to low arachidonoyl-CoA substrate levels.

This study shows that intestinal epithelial Axin1 deficiency reduces susceptibility to colitis by altering gut microbiota composition and Paneth cell function.

This study investigates whether prior SARS-CoV-2 infection affects influenza disease severity in ferrets, finding mild increased symptoms but no major histopathological changes.

This study identifies pancreatic Cowdry type A inclusion bodies as a specific histopathological marker for TiPV infection in Nile tilapia.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

This study identifies a Dst-b mutation causing late-onset myopathy and cardiomyopathy in mice, revealing its critical role in striated muscle maintenance.

This study analyzes global salivary gland tumor data from 15 centers to provide updated epidemiological insights on incidence, demographics, and tumor types.

This study identifies pericyte-mediated capillary constriction as a cause of no-reflow and kidney injury after ischemia, showing that targeting pericyte contractility can reduce injury.

This study shows hyperuricemia induces renal tubular epithelial pyroptosis via ROS-mediated NLRP3 inflammasome activation in cultured cells and rat models.