Discover, rate, and discuss biology preprints.

This study tracks SARS-CoV-2 infection progression in golden Syrian hamsters, showing weight loss, lung damage, and resolution over time.

This study shows that B6.Sst1S mice develop more severe pulmonary M. avium infection with increased type 2 macrophage activation and reduced T cell density compared to wild-type mice.

This study shows that expressing SARS-CoV-2 Spike S1 subunit in cardiomyocytes causes cardiac hypertrophy and inflammation via TLR4 activation, independent of ACE2.

The study examines APOL1 expression in the kidney using transgenic mice and finds it is not expressed in proximal tubules or filtered by them.

This study develops a semi-automated method for tumor budding assessment in colorectal cancer and compares it with manual methods, finding strong correlation and higher detection rates with the new approach.

This study shows that inhibiting EPAC1 protects the heart from doxorubicin-induced toxicity without affecting its cancer-killing effects.

This study shows that SARS-CoV-2 envelope protein disrupts cellular homeostasis by forming ion channels, leading to altered Ca2+ and pH levels and membrane depolarization.

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

This study shows that PIK3CA mutations drive hepatocarcinogenesis independently of RASSF1A status, with early Galectin-1 upregulation and synergistic therapeutic effects of PIK3CA and Galectin-1 inhibitors.

This paper develops a deep learning method to segment and quantify podocyte foot process morphology in kidney tissue, confirming morphological changes in disease states.

The paper uses metabolomic analysis in diverse mice to show that liver damage during Plasmodium chabaudi infection releases hepatic arginase-1 into plasma, contributing to arginine depletion.

This study identifies Stx2-induced differential gene expression and circadian rhythm disruption in proximal tubules, linking these changes to renal dysfunction.

This study shows that alpha-ketoglutarate inhibits Akt-driven thrombosis and inflammation by enhancing PHD2 activity and reducing pAkt1 levels in platelets and leukocytes.

The paper identifies novel pulmonary vein nodes as potential sources of ectopic arrhythmogenic foci in atrial fibrillation through immunohistochemical analysis of human tissue.

This paper introduces GraphITE, a deep learning pipeline that transforms multiplex immunofluorescence data into graph embeddings for exploratory analysis of tumor microenvironment patterns.

This study identifies predictors of cognitive impairment in primary age-related tauopathy (PART) using autopsy data, finding that p-tau burden and cerebrovascular disease are significant predictors.

This study evaluates hygienic behavior in honey bees to reduce Varroa infestation, finding it heritable and beneficial without major trade-offs.

This study investigates how different types of mechanical stress affect knee osteoarthritis onset and progression using animal models.

This study identifies ER stress, inflammation, and autophagy blockage as key mechanisms in joint degeneration in a mouse model of pseudoachondroplasia, suggesting potential therapeutic targets.