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This study shows that AaH-II selectively activates TTX-S Nav channels, inducing arrhythmias in cardiac tissue, and suggests targeting these channels as an antiarrhythmic strategy.

This paper introduces FibeRtypeR, a tool to estimate muscle fiber type proportions from bulk transcriptomics and proteomics data using single-fiber reference profiles.

This study shows that inhibiting FATP2 improves glucose tolerance via α-cell GLP-1 secretion and β-cell insulin release in diabetic mice.

This study examines how subjective exercise experience predicts depression in adolescents through two mediating pathways: sleep quality and fatigue.

This study shows that G5G8-independent mechanisms cannot compensate for G5G8 deficiency in mice fed a high cholesterol diet, leading to sterol accumulation in the liver and plasma.

This study investigates the role of Substance P and the NK1 receptor in aldosterone-producing adenomas, finding SP-positive nerve fibers and NK1R expression in most APA tissues and SP-induced aldosterone secretion.

This study investigates exercise-induced pain modulation in high-fit females, finding that fitness level, not sex, moderates pain relief from high-intensity exercise.

This study examines if increasing midsole thickness or compliance in running shoes affects metabolic cost and effective leg length, finding that compliance reduces metabolic cost while thickness increases leg length but raises metabolic cost.

This study shows that CaMKII phosphorylation of RYR2 at S2814 is essential for arrhythmia in CPVT, acting as an intra-molecular event.

This study shows that circadian rhythms in glycolysis and cell cycle progression are essential for cardiomyocyte proliferation and heart regeneration in zebrafish.

This study shows that oral N-acetylglucosamine improves spontaneous locomotor activity in mdx mice, with combined treatment enhancing effects compared to prednisolone alone.

This study examines the effects of ivermectin on immune activity and senescence in dung beetles, finding no immunosenescence but sex-specific immune responses.

This study uses 24-hour cross-recurrence plots to show that mother-child autonomic nervous system interactions predict maternal parenting stress better than individual analyses.

This study identifies sex differences in tubuloglomerular feedback dynamics in rodent kidneys, showing males have higher oscillation frequencies but are more prone to TGF loss, leading to increased injury risk.

This study examines the effects of Western diets on bank voles, finding resistance to obesity but altered liver function and metabolic pathways.

This study shows that microglial purinergic signaling reverses salt-induced neurovascular polarity in the hypothalamus during heart failure, restoring oxygen levels through adenosine A2A receptor-mediated vasodilation.

This paper introduces and validates a novel single-sprint test for assessing dynamic fatigue components during cycling, showing it outperforms traditional methods in accuracy and validity.

This study shows that antiretroviral therapy during pregnancy impairs postpartum cardiac reverse remodeling and may lead to early signs of heart failure with preserved ejection fraction.

The paper investigates the role of HaST46 in regulating trehalose metabolism in Helicoverpa armigera, showing a trade-off between exogenous uptake and endogenous synthesis.

This study compares cardiorespiratory responses to music in preterm infants and adults, finding similar HRV changes but distinct RSA and coupling patterns indicating different autonomic states.