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This study shows that TRB3 overexpression in skeletal muscle reduces exercise-induced adaptations by impairing glucose metabolism and mitochondrial biogenesis.

This study examines the impact of liver anatomical abnormalities on orthotopic liver transplantation outcomes in rats, finding that such abnormalities significantly reduce transplant success.

This study validates the IP ratio as a non-invasive indicator of welfare in laying hens, showing it is influenced by housing systems but not light or age.

The paper identifies a hindbrain neuron cluster, Sup5Phox2b, essential for coordinating biting and chewing during feeding.

The paper introduces PRAM, a decision matrix to distinguish individual physiological variation from experimental noise, showing aerobic metrics are more repeatable than non-aerobic ones in fish.

The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.

This study compares training and match running distances and perceived exertion at sea-level and altitude in elite soccer players, finding increased breathlessness relative to leg exertion at altitude.

This study compares adiponectin-deficient mice to show that intracellular globular adiponectin regulates adipose tissue metabolism by modulating PPARγ activity.

This study identifies the PPARD/PDK4/ANGPTL4 pathway as a mechanism by which obesity induces phenotypic switching of gastric smooth muscle cells, leading to dysmotility.

This paper critiques a study linking L-type calcium channel blockers to heart failure, identifying flaws in methodology, data interpretation, and mathematical analysis.

This study uses proteomic analysis to track tear fluid changes after PRK, identifying key molecular events in corneal repair and potential biomarkers for healing.

The paper shows high glucose levels reduce kidney protection during dehydration by inhibiting the FXR-TonEBP axis in diabetic patients and mice.

This study shows that body temperature, not ambient temperature, strongly regulates glucose metabolism and behavior in QIH mice, with hypometabolism being secondary to hypothermia.

This study examines Stab1 and Stab2 levels and their ligands in T2DM patients to assess their relationship with atherosclerotic plaque burden and lipid metabolism.

This study demonstrates that engineered tRNA can restore vision in a mouse model of Leber Congenital Amaurosis by suppressing a premature termination codon.

This study shows that inhibiting Epac1 with AM-001 reduces fibroblast proliferation and profibrotic markers, protecting against pulmonary fibrosis in mouse models and human lung slices.

This study uses latent curve models to analyze MTG data from Achilles tendons during ankle plantar flexion, revealing sex-specific trajectories of MTG increase with muscle strength.

This study identifies Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle, using a human SNP rs6190 in mice and human datasets.

This study identifies renin-lineage cell fate reprogramming and metabolic dysfunction as drivers of concentric arterial hypertrophy, with potential biomarkers for early detection.

This study shows that juvenile protein restriction in mice reduces sexual dimorphism by affecting somatic growth, energy metabolism, and hepatic molecular identity, with distinct adaptations in reproductive development.