Discover, rate, and discuss biology preprints.

The paper develops a spatial agent-based model of AGE-RAGE feedback in hepatic fibrosis, revealing stage-dependent irreversibility thresholds and sRAGE divergence.

The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.

This study evaluates the effects of the live biotherapeutic EcN::ttr on mice fed a proinflammatory diet, showing improvements in metabolic, inflammatory, and behavioral outcomes.

The paper benchmarks optimization methods for parameter estimation in life sciences, identifying performance tiers and proposing a hybrid strategy that improves solution quality and robustness.

InferAging quantifies biological aging by modeling deviations from chronological age, identifying accelerated and delayed agers in zebrafish using non-invasive phenotypes.

This study examines the relationship between root phenotypes and rhizosphere microbial diversity in maize under drought and optimal conditions, finding that root anatomy, not architecture, is more strongly associated with microbial diversity.

This study shows that chicory reduces cyathostomin parasites and alters gut microbiota in horses without affecting host physiology.

This paper introduces a framework to convert continuous neural network attributions into testable biological hypotheses using decision trees and language models, validated on single-cell omics data.

The paper introduces monocyteMINER, a method using monocyte transcriptomes to discover disease-specific biomarkers, showing improved performance for atherosclerosis and tuberculosis.

This study models how Salmonella uses regulatory memory and growth-coupled inheritance to adjust flagellar number based on nutrient availability.

The paper develops a model-based analysis of how p53 stress memory influences JAK/STAT1 antiviral signaling, showing it redistributes STAT1 activity and affects viral control outcomes.

This study shows that insulin signaling modulates the genomic response to aging and heat stress by switching between modular and integrated regulatory states in Drosophila.

The paper distinguishes between buckling and angiogenesis in blood vessel tortuosity using spectral analysis of vessel morphology.

The paper examines differences between suspended and sinking particles during a Phaeocystis bloom, showing that particle composition and bloom stage significantly affect carbon flux in the mesopelagic zone.

The paper identifies TF-DNA binding interactions at cytokine promoters, showing that TF cooperativity and antagonism significantly influence DNA-binding specificity.

The paper introduces two benchmark datasets for drug repurposing across rare diseases: a positive dataset from clinical trials and a negative dataset from disease ontologies, enabling evaluation of computational models for disease-drug associations.

The paper presents an AI framework integrating large language models with laboratory automation for systems biology, validated in yeast to identify novel interactions and improve hypothesis validation.

This paper develops an AI-guided framework for personalized cancer immunotherapy dosing, achieving high remission rates with lower median doses compared to fixed regimens.

This study identifies five proteins whose sequential changes in plasma precede spontaneous labour onset, implicating the IL-33/ST2 axis in labour timing and identifying LMOD1 as a novel marker.

This study identifies metabolite ratios using generalized linear models to diagnose peritoneal endometriosis with high accuracy from plasma samples.