Discover, rate, and discuss biology preprints.

PROTFIG automates the creation of publication-quality biomolecular figures from structural data with minimal manual input.

This paper introduces a non-invasive method to study localized mechanical forces in 3D epithelial tissues using elastic microbeads and shows how cytoskeletal remodeling and adhesion organization respond to mechanical perturbations.

This study identifies a pathway by which SARS-CoV-2 Spike activates PIEZO1-sphingomyelinase signaling to promote cell-cell fusion through ceramide generation and phosphatase-mediated actin cortex detachment.

This study examines how undergraduate biology students used AI-enabled feedback to revise their scientific writing, finding they addressed about half of the feedback comments but struggled with more demanding revisions.

Serratus-guided Snakemake mining, expert curation, clustering and phylogenetic placement identify at least 32 putative novel tobamoviruses in public short-read data, mostly Amazon River metatranscriptomes; a random-forest classifier partly automates curation.

This study identifies Survivin as a critical KRAS signaling partner that promotes glycolytic activity in PDAC cells by forming microtubule-based complexes with glycolytic enzymes.

This study identifies sex-associated epigenetic and transcriptional programs in muscle-invasive bladder cancer, showing distinct DNA methylation and gene expression patterns between males and females, with conservation in a mouse model.

This study examines spatial segregation and multi-scale space-use adjustments in western gorillas, finding that home range shifts and daily movements are influenced by socio-ecological factors rather than territorial behavior.

This study shows NMD limits TE-driven transcriptomic innovation by degrading TE-derived transcripts, affecting evolutionary novelty and cancer outcomes.

This study uses molecular dynamics simulations to investigate hERG ion permeation and how small molecules modulate it, revealing structural mechanisms and binding modes.

Streamline CNV is a Nextflow pipeline for CNV analysis that simplifies processing, visualization, and interpretation of copy number data across various sequencing types and species.

This study identifies annexin 5 as a key regulator of RNA reservoir formation in Arabidopsis pollen by modulating ribosome biogenesis and RNA availability.

This paper presents a cell-free method to rapidly produce and determine cryo-EM structures of GPCR-nanodisc complexes, achieving structural-grade results in four days.

This study investigates how CTCF's functional properties evolved across bilaterian species, revealing gradual changes in its ability to regulate chromatin structure and transcription.

This study shows that 13C-MFA in E. coli is sensitive to biomass composition, emphasizing the need for accurate biomass formulations in flux analysis.

The paper develops a model to predict prey capture performance and growth rate in heliozoans based on axopod characteristics.

The paper generates iPSCs from a Parkinson's patient with a RAB32 mutation and confirms their pluripotency and differentiation potential.