Discover, rate, and discuss biology preprints.

The paper introduces a data model for longitudinal multimodal biomedical cohorts, demonstrating its ability to manage heterogeneous data across multiple modalities and study visits.

This study shows that reducing nitrate supply under salt stress improves tomato fruit quality and mitigates chlorophyll loss, with transcriptomic changes supporting these physiological benefits.

This paper introduces an Oxford Nanopore sequencing framework for hantavirus genome assembly and variant analysis, revealing defective viral genomes as a new feature of hantavirus populations.

This study shows that etoposide-treated B16-Ova melanoma cells upregulate B2M and lose tumor-forming potential while remaining viable and stimulating T-cell activation.

This paper develops a high-throughput fluorescence anisotropy assay to measure peptidoglycan-digesting enzyme activity, enabling rapid and specific analysis of enzyme-substrate interactions.

This study shows that phosphorylation of CARM1 at Ser572 is essential for maintaining muscle stem cell self-renewal by preventing premature myogenic commitment.

This paper develops a 3D bioprinting method to create engineered skeletal muscle with controlled myofibre architecture, demonstrating functional tissue with various fibre orientations.

This study identifies NEIL2 as a regulator of RNA polymerase II dynamics that suppresses transcription replication conflicts in pancreatic cancer cells.

This study identifies BNIP3L/NIX-mediated mitophagy as a critical pathway that limits Alzheimer's disease pathology and preserves neuronal function by maintaining mitochondrial health and reducing proteotoxicity.

This study designs synthetic activators for programmable gene expression by engineering coactivator-binding proteins and demonstrates their enhanced transcriptional activation capabilities.

This study shows extracellular Orientia tsutsugamushi contributes to systemic dissemination and that gentamicin reduces bacterial growth in a murine model.

This paper introduces optimal transport to explicitly reveal cell correspondences in single-cell multi-omics, improving integration and label transfer by identifying and removing ambiguous cells.

The paper identifies a splicing enhancer sequence that recruits factors for VSG mRNA maturation and proposes a model where polyadenylated SL RNA precursors are substrates for trans-splicing.

The paper characterizes SNARE-like proteins from Heimdallarchaeota, showing their four-helix bundle structure and evolutionary relationship to eukaryotic SNARE complexes.

This study identifies a thymus-specific B-cell differentiation program linked to thymic B-cell lymphomagenesis through single-cell multiomics and spatial profiling.

This study examines how pancreatic islets respond to different oxygen levels and reoxygenation, finding that viability decreases under hypoxia but is preserved at 5% and 18% O2, with reoxygenation not fully restoring viability.

This study reveals how viral helicases initiate DNA replication by deforming DNA through flexible CTDs, coupling self-loading with initial melting.

This paper shows that combining GLP1R agonists with vorasidenib induces synergistic cytotoxicity in mIDH glioma by generating peroxynitrite through mitochondrial redox metabolism.

The paper investigates how perception reacts to tangible vs virtual impossible objects, finding that real objects create more surprise and perceptual impact than 2D representations.