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Model-Agnostic Decomposition of the Difference in Mean Response Between Two Groups via Game-Theoretic Attribution with Minimum-Switching-Distortion Coupling

This paper introduces a model-agnostic decomposition method to analyze differences in mean response between groups, using game-theoretic attribution and optimal transport coupling.

LRCQ: phenome-wide heritability enrichment of genomic loci from GWAS summary statistics

LRCQ estimates phenome-wide heritability enrichment of genomic loci using GWAS summary statistics, identifying enriched regions and their functional annotations.

Unilateral naris occlusion with custom-made plugs for reversible olfactory deprivation in juvenile and adult mice

The paper describes a method for reversible olfactory deprivation in mice using custom-made nose plugs and validates its effectiveness in post-weaning animals.

Structural basis of nucleosome recognition by the human NuA4/TIP60 acetyltransferase complex

This study presents the structure of the human TIP60-C HAT module bound to a nucleosome, revealing how it positions the catalytic center on the nucleosome surface and engages the linker DNA.

Perturbation-induced gene programs map the hidden regulatory architecture of complex diseases

This paper introduces Perturbscape, a framework that uses perturbation-induced gene programs to identify disease-relevant genes and pathways, showing higher heritability informativeness than steady-state approaches.

CD200R1 Marks a Branchpoint During Human Natural Killer Cell Development in Tonsils

The paper identifies CD200R1 as a marker for an immature NK-cell precursor in tonsils, distinguishing between oligopotent and more restricted developmental stages.

A conserved thermodynamic signature links transcriptome organization to growth state

The paper develops a thermodynamic model linking transcriptome organization to growth state by analyzing RNA folding free energies across cell cycle and stress adaptation.

GeneFamHunter: annotation-independent recovery of divergent and tandemly arrayed gene-family members from genome assemblies

GeneFamHunter recovers gene-family members from genome assemblies, outperforming existing methods in identifying divergent and tandemly arrayed genes.

HOX13 factors shape cell developmental transcriptional program through multiple mechanisms that regulate chromatin accessibility.

This study shows HOX13 factors regulate chromatin accessibility through homodimerization and SWI/SNF recruitment, influencing lineage-specific transcriptional programs in iPSCs.

Structural and evolutionary insights into FcαμR recognition of polymeric immunoglobulins

This study determines cryo-EM structures of FcR bound to IgM and IgA, revealing its binding mechanism and evolutionary insights into pIg receptor recognition.

Deep Recovery of Effective Migration Surfaces

This paper introduces dreems, a graph neural network that efficiently estimates effective migration surfaces from genetic data, achieving lower error and faster computation than existing methods.

Gain Control of Peripheral Input by Core Brain Thermosensors Drives Drosophila Thermoregulation

The paper identifies core brain thermosensors in Drosophila larvae that regulate thermoregulation by modulating the behavioral response to peripheral temperature inputs.

Neural RNA splicing models rely on reading frame information unavailable to the splicing machinery

The paper shows that neural RNA splicing models rely on reading frame information that the splicing machinery cannot access, leading to errors in predicting poison exons.

Chromosome folding encodes mechanisms of cohesion maintenance

The paper shows how changes in sister chromatid folding over time encode mechanisms of cohesion maintenance, revealing how transient cofactor interactions regulate long-lived cohesin protection.

The intrinsically disordered N-terminal region of eIF5B nucleates RNA-driven phase separation

This study shows that the intrinsically disordered N-terminal region of eIF5B drives RNA-driven phase separation in vitro and validates this in cells.

Microtubules coordinate with actin assembly and disassembly to elongate cortical actin cables

The paper shows microtubules coordinate with actin assembly and disassembly to maintain cortical actin cable elongation in Drosophila nurse cells.

Joint effects of climate change and urbanization accelerate plant biodiversity loss across urban green spaces

This study shows that climate change and urbanization together reduce plant biodiversity in urban green spaces, with allotments and ruderal areas being most affected.

Algal turf sediment dynamics across the Florida Reef Tract

The paper quantifies algal turf and sediment dynamics across four reef positions in the Florida Reef Tract, finding higher sediment loads and longer turfs nearshore compared to offshore.

Mechanisms of impaired cerebral hemodynamics and memory resilience differ by sex: A role for mineralocorticoid receptors in VCID

This study investigates sex-specific effects of hypertension on cerebral hemodynamics and memory, finding that MR antagonism improves perfusion and memory in female rats but not males.

An orphan LuxR regulator controls plant developmental reprogramming during interaction with Novosphingobium resinovorum HR1a

This study identifies LuxR874 as a bacterial regulator that modulates plant developmental reprogramming during rhizoremediation by altering host gene expression and physiological responses.