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This study identifies how Yersinia pseudotuberculosis uses YopE and YopH to inhibit neutrophil degranulation and ROS production through distinct pathways.

HiFIseek identifies gene-specific enrichment of high-impact mutations in genomic regions associated with cancer and breast cancer risk SNPs, showing limited agreement across CRR-score combinations.

The paper identifies Gardos as an amplifier of PIEZO1-TMEM16F signaling in red blood cells, enhancing Ca2+ entry and PS externalization, and suggests it as a therapeutic target for diseases like sickle cell disease.

This study identifies proteins secreted by Francisella tularensis using BONCAT and proteomics, validating T4P-mediated secretion of ChiA, ChiD, and KatG.

This study uses dual-modality imaging to assess therapy-induced changes in tumor vascular function and oxygenation, revealing spatial heterogeneity in response to photodynamic therapy.

The paper shows orangutan mothers adjust their ranging behavior to increase offspring social play, at an energetic cost.

This paper identifies DD-CPases as the source of tetrapeptides for LDTs in C. difficile and shows that LDTs are essential due to high DD-CPase activity, not for divisome/elongasome function.

This study identifies an ATG8-independent autophagy-like pathway in Giardia lamblia regulated by GlRac, showing structural and functional similarities to canonical autophagy despite lacking most ATG genes.

This paper compares the mechanisms driving lesion outcomes in lung tumors and tuberculosis granulomas using agent-based models to study immune-tumor interactions and treatment responses.

This study shows that neutrophil-derived oncostatin M (OSM) contributes to endothelial dysfunction during Treponema denticola infection, linking periodontitis to cardiovascular disease.

This study uses a CRISPR screen to identify genes critical for erythroblast enucleation, finding CLIC3 and VAMP8 as key factors with distinct roles in the process.

This study analyzes bacterial communities in coenocytic algae using metagenome-assembled genomes, finding high dominance of Pseudomonadota and unique biosynthetic gene clusters in coenocytic MAGs.

This study identifies cyanoquinoline-based HIPK4 inhibitors with nanomolar potency and reveals their cell-type-specific effects on HIPK4 proteostasis and autophagy.

The paper investigates how β-tubulin isotypes TBB-1 and TBB-2 contribute to acentrosomal spindle bipolarity and function in C. elegans oocytes.

This paper develops a computational pipeline to quantify antibiotic susceptibility and inoculum effects in Pseudomonas aeruginosa by analyzing transient dynamics and identifying a novel mathematical model.

This study shows that dimerization of PARP15 is necessary for NAD+ binding and automodification, supported by structural and biochemical evidence.

The paper identifies RTT109 as essential for maintaining PRC2-repressed chromatin in Neurospora crassa, showing it is required for epigenetic memory but not H3K56 acetylation.

This study shows that macaque monkeys develop habitual manual choices toward previously rewarded objects, driven by learned value and spatial preferences, with reaching habits persisting without reward and showing shorter latencies than value-deliberative tasks.

This paper describes a standardized protocol for creating mouse models of bisphosphonate-related and radiation-induced jaw osteonecrosis using minimally invasive surgical and irradiation techniques.