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This study uses untargeted sequencing to analyze population genetics and pathogen surveillance in timber rattlesnakes, finding genetic distinctness and a color variation locus linked to ALDH4A1.

The paper shows XyG-synthesizing glycosyltransferases traffic independently to the Golgi, have distinct sub-Golgi localization, and vary in stability, revealing mechanisms of protein interactions and complex assembly.

This paper identifies a small molecule that enhances translational fidelity in mycobacteria without reducing translation speed, targeting ribosomal protein S5 to combat antibiotic tolerance.

This study shows that environmental conditions and age influence chromatophore density and size in squid, revealing a trade-off between number and expansion of color cells.

The paper argues that behavioral measures of multisensory integration are composite and misinterpreted, proposing a model-based inference pipeline to disentangle underlying factors.

replicateFest uses negative binomial models for replicated and Fisher's exact tests for unreplicated FEST TCR-seq to call antigen-expanded clonotypes, recovering all nine published HIV-1 responders.

The paper investigates a dual-strategy approach using a muscle-tropic AAV capsid and muscle-specific promoter to improve gene delivery efficiency and reduce off-target expression in skeletal muscle.

This paper introduces TAMOHA, a biochemical probe that enables comprehensive profiling of electrophilic metabolites, revealing thousands of previously uncharacterized species in E. coli, C. elegans, and mouse.

This study identifies tumor-intrinsic stress states as modulators of CAR T cell therapy response in pancreatic cancer using CRISPR screens and single-cell genomics.

This paper uses deep learning to analyze fossil grass pollen morphology and reconstruct 25,000 years of ecological change in East African grasslands, showing reduced diversity and shifts in C3:C4 ratios during the last ice age.

This paper develops a time-informed Adverse Outcome Pathway (AOP) network for environmental chemical-induced cardiotoxicity using data-driven methods and identifies key processes linking perturbations to cardiac injury.

This study compares the long-term effects of repeated heroin vapor inhalation during adolescence versus adulthood in female rats, finding lasting impacts on nociception and anxiety-like behavior, with more pronounced effects in adolescents.

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

The paper introduces ThermoTargetMiner, a database that identifies protein targets of lung cancer therapeutics using the PISA assay, revealing novel targets for 77% of tested compounds.

This paper develops an fMRI method to measure contrast sensitivity across the visual field without requiring precise fixation, showing reliable patterns and tolerance to eye movement.

This study maps allele-specific expression in human kidney disease, finding increased glomerular ASE associated with better disease outcomes.

This study examines how behavioural activity affects EEG power spectrum, source localization, and global functional connectivity in freely moving rats, identifying specific frequency band changes.

DESPOT improves protein-ligand docking by introducing anisotropic scoring potentials that outperform isotropic methods in docking accuracy and virtual screening.

This study identifies AHA, a conserved archaeal ribosome-associated factor involved in hibernation and energy sensing, linking prokaryotic translational silencing to eukaryotic energy sensing.

This paper develops a cell-based therapy that enables sustained, dose-tunable delivery of monoclonal antibodies through a single administration, demonstrating long-term efficacy and safety in preclinical models.