A. Abdollahi

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse

This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.

Reprogramming M2-polarized patient-derived glioblastoma associated microglia/macrophages via CSF1R inhibition

This study shows that GW2580 reprograms M2-like glioblastoma-associated macrophages to M1-like cells, enhancing phagocytosis and T-cell killing, and reduces tumor cell proliferation in patient-derived organoids.

Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model

This study shows that carbon ion radiotherapy combined with CTLA4 blockade induces complete tumor rejection and systemic immune memory in a murine tumor model.

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

This study shows that glutamine catabolism via GLS regulates redox state, stemness, and autophagy in prostate cancer, affecting radiosensitivity and patient outcomes.

Carbon ion dosimetry on a fluorescent nuclear track detector using widefield microscopy

This paper demonstrates that widefield microscopy can efficiently read out fluorescent nuclear track detectors after carbon ion irradiation, offering a faster alternative to laser scanning confocal microscopy.

The biomedical sensor Cell-Fit-HD4D, reveals individual tumor cell fate in response to microscopic ion deposition.

The paper introduces a biomedical sensor, Cell-Fit-HD4D, to monitor individual tumor cell fate after ion beam therapy and demonstrates its ability to visualize ion beams and track cell responses.