A. Casadevall

The paper generates a monoclonal antibody against HSP90 in Paracoccidioides fungi that opsonizes fungal cells and enhances macrophage uptake, suggesting potential for immunotherapy.

This study shows that faster melanization in Cryptococcus species correlates with increased virulence and worse patient outcomes.

This study evaluates the antifungal activity of six 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against two human pathogenic fungi, showing some compounds have low MIC and cause cell surface damage.

This study shows glyphosate inhibits melanin production in insects, reducing their survival after infection and increasing susceptibility to pathogens.

This study shows fungi are colder than their surroundings due to evapotranspiration, with implications for cooling systems and planetary temperature regulation.

The paper shows macrophages use a bet-hedging strategy by stochastically acidifying phagolysosomes to reduce variation in antimicrobial effectiveness.

This study uses a hydroxylamine-armed fluorescent probe to investigate the structure and assembly of the Cryptococcus neoformans capsule, revealing reducing ends at the cell wall surface.

This study shows that variation in cell surface hydrophobicity among Cryptococcus neoformans strains affects their interaction with amoeba and antibody binding.

This study shows that intranasal infection with Cryptococcus neoformans in mice leads to rapid brain dissemination and nasal colonization within hours.

This paper demonstrates that Cryptococcus neoformans can enter a viable but non-culturable state under specific in vitro conditions, characterized by reduced metabolism and reactivation potential.

This study uses phylogenetic analysis to suggest Candida auris may be the first fungal disease emerging from climate change, despite its simultaneous emergence in three continents with distinct genetic clades.

This study identifies the structural unit of melanin in the fungal pathogen Cryptococcus neoformans, revealing its organization into nanospheres and granules.

The paper investigates Cryptococcus neoformans transfer between macrophages, finding that it occurs via a non-lytic process involving exocytosis and phagocytosis, termed Dragotcytosis.

This study shows that soil amoebae interact with Paracoccidioides spp., increasing fungal virulence through the accumulation of cell wall alpha-glucans.

This study shows Galectin-3 inhibits Paracoccidioides brasiliensis growth and affects extracellular vesicle stability, suggesting a direct antimicrobial role in paracoccidioidomycosis.

This study shows that secreted molecules from Cryptococcus neoformans inhibit inflammasome-dependent macrophage responses, reducing antifungal activity and enhancing fungal survival.

This study investigates the role of annexins in Cryptococcus neoformans, finding that the annexin gene is not essential for virulence or mating but affects titan cell formation.

This study shows that the capsule of Cryptococcus neoformans buffers phagosomal acidification, interfering with host defense mechanisms.

This study develops a method to observe Cryptococcus neoformans capsule dynamics in real-time without opsonins, revealing capsule distribution during budding.

This study identifies environmental and genetic factors that regulate titan cell formation in Cryptococcus neoformans using an optimized in vitro assay.

The paper shows serum cleaves Bacillus anthracis Protective Antigen in two steps: first by splitting PA83 into PA63 and PA20, then removing terminal residues via carboxypeptidase.

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.

The paper analyzes gender ratios in authorship of publications with equal contributions, finding male predominance in first author positions and mixed gender pairs.

This study shows that Mg2+ and Ca2+ enhance A. castellanii's ability to kill C. neoformans by improving phagocytosis and adhesion.

The paper reports the first draft genome sequence of Lomentospora prolificans, assembled using Illumina and Oxford Nanopore reads, resulting in a highly contiguous genome with 8,656 protein-coding genes.

This study investigates factors influencing scientific misconduct by analyzing papers with image duplications, finding that country-level policies and academic culture significantly impact research integrity.