R. Luo

OsAAI1-OsMADS25 module orchestrates root morphogenesis by fine-tuning IAA in drought stressed rice

This study shows that OsAAI1 and OsMADS25 regulate rice root growth and drought resistance by modulating IAA levels and downstream gene expression.

Bacterial-tyramine-induced renal-gut countercurrent flow regulates gut immune response by promoting ROS accumulation and gut peristalsis in the fly Bactrocera dorsalis

The paper identifies a renal-gut countercurrent flow in fruit flies that enhances gut immune response by promoting ROS accumulation and peristalsis through bacterial tyramine recognition.

Gut bacteria-derived serotonin promotes immune tolerance in early life

This study shows that neonatal gut bacteria produce serotonin, which promotes immune tolerance by inhibiting mTOR and increasing regulatory T cells.

A self-blinking DNA probe for 3D superresolution imaging of native chromatin

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

DNA methylation affects pre-mRNA transcriptional initiation and processing in Arabidopsis

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

ssc-micorRNA-132 suppresses the Clostridium perfringens beta2 toxin induced inflammation and apoptosis of IPEC-J2 cells via targeting DACH1

This study shows that ssc-miR-132 reduces inflammation and apoptosis in IPEC-J2 cells caused by C. perfringens beta2 toxin by targeting DACH1.

Modeling SARS-CoV-2 infection in vitro with a human intestine-on-chip device

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

Pairing two growth-based, high-throughput selections to fine tune conformational dynamics in oxygenase engineering

This paper introduces two growth-based selections in E. coli to engineer CHMO with improved thermostability and NADH cofactor specificity.

Acetylation is required for NLRP3 self-aggregation and full activation of the inflammasome

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

First Draft Genome Sequence of the Pathogenic Fungus Lomentospora prolificans (formerly Scedosporium prolificans)

The paper reports the first draft genome sequence of Lomentospora prolificans, assembled using Illumina and Oxford Nanopore reads, resulting in a highly contiguous genome with 8,656 protein-coding genes.