Author

Y. Manchanda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Assay:proteomics· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Tomas· 5 shared B. Jones· 5 shared A. Inoue· 2 shared G. A. Rutter· 2 shared L. ElEid· 2 shared S. Bitsi· 2 shared A. I. Oqua· 1 shared A. Montoya· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersCell Biology

A. Tomas

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Author profile →

5 papers

Recent·Most cited

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

G. Austin, A. I. Oqua, L. ElEid, M. Zhu, Y. Manchanda, P. Peres, H. Coyle, Y. Poliakova, K. Bouzakri, A. Montoya, D. J. Withers, M. Solimena, B. Jones, S. J. Millership, S. Burgold, , A. Tomas

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

bioRxiv · Apr 28, 2024Cell Biology

An examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells

Y. Manchanda, S. Bitsi, S. Chen, J. Broichhagen, J. Bernardino de la Serna, B. Jones, A. Tomas

This study compares the trafficking and signaling of GLP-1R and GIPR in pancreatic beta cells, revealing differences in internalization, recycling, and subcellular activity.

bioRxiv · Aug 17, 2022 · PreprintCell Biology

Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice

S. Bitsi, Y. Manchanda, L. ElEid, N. Mohamed, B. Hansen, K. Suba, G. A. Rutter, V. Salem, B. Jones, A. Tomas

This study examines GLP-1R responses in beta cell-specific β-arrestin 2 knockout mice, finding acute deficits and prolonged effects with certain agonists.

bioRxiv · Apr 21, 2022 · PreprintCell Biology

Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling

Y. Manchanda, Z. Ramchunder, M. M. Shchepinova, G. A. Rutter, A. Inoue, E. W. Tate, B. Jones, A. Tomas

This paper shows that mini-G proteins block GPCR trafficking and signaling by preventing receptor internalization, and proposes a nanobody-based alternative assay.

bioRxiv · Nov 24, 2021 · PreprintCell Biology

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

E. R. McGlone, Y. Manchanda, B. Jones, P. Pickford, A. Inoue, D. Carling, S. R. Bloom, T. M. Tan, A. Tomas

This study investigates how RAMP2 affects GCGR trafficking and signaling in hepatocytes, showing it alters receptor internalization and signaling bias with limited metabolic impact.

bioRxiv · May 9, 2021Cell Biology