B. L. Yount

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

The paper shows that inhibiting the kinase CSNK2 blocks replication of several beta-coronaviruses, including SARS-CoV-2, by preventing viral entry.

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding and cytopathogenicity

This study maps host-driven post-translational modifications on the Zika virus proteome, identifies key phosphosites, and shows how an FDA-approved kinase inhibitor blocks viral growth.

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

This paper develops a mouse-adapted SARS-CoV-2 model to evaluate medical countermeasures, showing age-related disease severity and the efficacy of IFN lambda-1a.

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

This study shows that disrupting MERS-CoV NSP16's 2O methyl-transferase activity attenuates viral pathogenesis and provides a live attenuated vaccine platform.