G. M. Taylor

Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories

This paper determines the structure of the reovirus σNS RNA chaperone and shows how its oligomeric state and N-terminal arm regulate RNA binding and chaperone activity.

A gut commensal protist protects against virus-mediated loss of oral tolerance

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.

The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection

This study identifies how NgR1 bridges reovirus capsid proteins to initiate infection, revealing a unique binding interface and its role in virus entry and receptor ligand interactions.

Neuron-intrinsic NF-κB Signaling Mediates Reovirus Virulence

This study shows that neuron-intrinsic NF-κB signaling is critical for reovirus-induced neuronal apoptosis and virulence in mice.