Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
P. Zhou, G. Song, W.-t. He, N. Beutler, L. V. Tse, D. R. Martinez, A. Schafer, F. Anzanello, P. Yong, L. Peng, K. Dueker, R. Musharrafieh, S. Callaghan, T. Capozzola, M. Yuan, , R. Andrabi
The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.
bioRxiv · Mar 4, 2022Immunology
K. H. Dinnon, S. R. Leist, K. Okuda, H. Dang, E. J. Fritch, K. L. Gully, G. Cruz, M. D. Evangelista, T. Asakura, R. C. Gilmore, P. Hawkins, S. Nakano, A. West, A. Schäfer, L. E. Gralinski, , Montg
This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.
bioRxiv · Feb 15, 2022 · PreprintMicrobiology
W.-t. He, R. Musharrafieh, G. Song, K. Dueker, L. V. Tse, D. R. Martinez, A. Schafer, S. Callaghan, P. Yong, N. Beutler, J. L. Torres, R. M. Volk, P. Zhou, M. Yuan, H. Liu, , R. Andrabi
This study isolates a panel of broadly neutralizing antibodies against SARS-like viruses from donors, showing effectiveness against multiple variants including Omicron.
bioRxiv · Sep 8, 2021Immunology
A. Schafer, L. E. Gralinski, S. R. Leist, E. S. Winkler, B. K. Hampton, M. A. Mooney, K. L. Jensen, R. L. Graham, S. Agnihothram, S. Jeng, S. Chamberlin, T. A. Bell, D. T. Scobey, L. A. VanBlargan, L. B. Thackray, , R. S. Baric
The paper identifies host susceptibility loci for SARS-CoV and SARS-CoV-2 using GWAS and Collaborative Cross datasets, validating CCR9 as a key regulator of severe disease outcomes across species.
bioRxiv · May 14, 2021 · PreprintMicrobiology
C. G. Rappazzo, L. V. Tse, C. I. Kaku, D. Wrapp, M. Sakharkar, D. Huang, L. M. Deveau, T. J. Yockachonis, A. S. Herbert, M. B. Battles, C. M. O'Brien, M. E. Brown, J. C. Geoghegan, J. Belk, L. Peng, , L. M. Walker
This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.
bioRxiv · Nov 17, 2020 · PreprintImmunology
Y. J. Hou, S. Chiba, P. Halfmann, C. Ehre, M. Kuroda, K. H. Dinnon, S. R. Leist, A. Schäfer, N. Nakajima, K. Takahashi, R. E. Lee, T. M. Mascenik, C. E. Edwards, L. V. Tse, R. C. Boucher, , R. S. Baric
This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.
bioRxiv · Sep 28, 2020Microbiology
A. O. Hassan, N. M. Kafai, I. P. Dmitriev, J. M. Fox, B. Smith, I. B. Harvey, R. E. Chen, E. S. Winkler, A. W. Wessel, J. B. Case, E. Kashentseva, B. T. McCune, A. L. Bailey, H. Zhao, L. A. VanBlargan, , M. S. Diamond
A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.
bioRxiv · Jul 16, 2020 · PreprintMicrobiology
S. J. Zost, P. Gilchuk, J. B. Case, E. Binshtein, R. E. Chen, J. X. Reidy, A. Trivette, R. S. Nargi, R. E. Sutton, N. Suryadevara, L. E. Williamson, E. C. Chen, T. Jones, S. Day, L. Myers, , J. E. Crowe
The paper identifies potent neutralizing antibodies against SARS-CoV-2 that block receptor binding and protect animals, providing insights for vaccine and therapy development.
bioRxiv · May 22, 2020Immunology
W. Li, A. Drelich, D. R. Martinez, L. E. Gralinski, C. Chen, Z. Sun, A. Schäfer, S. R. Leist, X. Liu, D. V. Zhelev, L. Zhang, E. L. Peterson, A. Conard, J. W. Mellors, C.-T. Tseng, , D. S. Dimitrov
This study rapidly identifies a potent human monoclonal antibody against SARS-CoV-2 that neutralizes the virus in animal models and shows promise for therapeutic use.
bioRxiv · May 13, 2020 · PreprintMicrobiology
K. H. Dinnon, S. R. Leist, A. Schafer, C. E. Edwards, D. R. Martinez, S. A. Montgomery, A. West, B. L. Yount, Y. J. Hou, L. E. Adams, K. L. Gully, A. J. Brown, E. Huang, M. D. Bryant, I. C. Choong, , R. S. Baric
This paper develops a mouse-adapted SARS-CoV-2 model to evaluate medical countermeasures, showing age-related disease severity and the efficacy of IFN lambda-1a.
bioRxiv · May 6, 2020Microbiology
A. J. Pruijssers, A. S. George, A. Schäfer, S. R. Leist, L. E. Gralinski, K. H. Dinnon, B. L. Yount, M. L. Agostini, L. J. Stevens, J. D. Chappell, X. Lu, T. M. Hughes, K. L. Gully, D. R. Martinez, A. J. Brown, , T. P. Sheahan
This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.
bioRxiv · Apr 27, 2020Microbiology
V. D. Menachery, L. E. Gralinski, H. D. Mitchell, K. H. Dinnon, S. R. Leist, B. L. Yount, R. L. Graham, E. T. McAnarney, K. G. Stratton, A. S. Cockrell, K. Debbink, A. C. Sims, K. M. Waters, R. S. Baric
This study shows that disrupting MERS-CoV NSP16's 2O methyl-transferase activity attenuates viral pathogenesis and provides a live attenuated vaccine platform.
bioRxiv · Aug 8, 2017Microbiology