Re-investigating the coughing rat model of pertussis to understand Bordetella pertussis pathogenesis
J. Hall, J. Kang, S. M. Kenney, T. Y. Wong, G. J. Bitzer, C. O. Kelly, C. A. Kisamore, D. Boehm, M. A. DeJong, M. A. Wolf, E. Sen-Kilic, A. M. Horspool, J. R. Bevere, M. Barbier, F. H. Damron
This study uses a rat model to compare disease manifestations between two genetically distinct Bordetella pertussis strains, finding that D420 induces more severe coughing and immune responses than Tohama 1.
bioRxiv · Apr 2, 2021Immunology