Author

M. Riffle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:benchmarking· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. J. MacCoss· 6 shared A. Zelter· 3 shared C. C. Wu· 3 shared T. N. Davis· 3 shared A. N. Hoofnagle· 2 shared B. X. MacLean· 2 shared D. L. Plubell· 2 shared E. Huang· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiochemistry

M. J. MacCoss

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A framework for quality control in quantitative proteomics

K. A. Tsantilas, G. E. Merrihew, J. E. Robbins, R. S. Johnson, J. Park, D. L. Plubell, J. D. Canterbury, E. Huang, M. Riffle, V. Sharma, B. X. MacLean, J. Eckels, C. C. Wu, M. S. Bereman, S. E. Spencer, , M. J. MacCoss

The paper introduces a framework for quality control in quantitative proteomics, combining internal and external QC measures with tools for data analysis and deposition.

bioRxiv · Apr 12, 2024Biochemistry

Resilience in a time of stress: revealing the molecular underpinnings of coral survival following thermal bleaching events

B. L. Nunn, T. Brown, E. B. Timmins-Schiffman, M. Mudge, M. Riffle, J. Axworthy, J. Dilwort, C. D. Kenkel, J. Zaneveld, L. Rodrigues, J. R. Padilla-Gamino

This study identifies molecular biomarkers of coral resilience to thermal bleaching by comparing proteomic, microbiome, and physiological traits of surviving and dying corals.

bioRxiv · Apr 2, 2024 · PreprintEcology

Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome

C. C. Wu, K. A. Tsantilas, J. Park, D. L. Plubell, J. A. Sanders, P. Naicker, I. Govender, S. Buthelezi, S. Stoychev, J. Jordaan, G. E. Merrihew, E. Huang, E. D. Parker, M. Riffle, A. N. Hoofnagle, , M. J. MacCoss

Mag-Net enriches membrane-bound particles from plasma to identify disease-specific proteins, discovering 204 proteins differentiating Alzheimer's disease dementia from controls.

bioRxiv · Jun 10, 2023 · PreprintBiochemistry

Evaluating the performance of the Astral mass analyzer for quantitative proteomics using data independent acquisition

L. R. Heil, N. E. Damoc, T. N. Arrey, A. Pashkova, E. Denisov, J. Petzoldt, A. Peterson, C. Hsu, B. C. Searle, N. Shulman, M. Riffle, B. Connolly, B. X. MacLean, P. M. Remes, M. Senko, , M. J. MacCoss

The paper evaluates the Astral mass analyzer's performance in quantitative proteomics, showing it quantifies 5 times more peptides per unit time than existing Orbitrap mass spectrometers and detects over 5,000 plasma proteins.

bioRxiv · Jun 3, 2023 · PreprintBiochemistry

Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry.

M. Riffle, M. R. Hoopmann, D. Jaschob, G. Zhong, R. L. Moritz, M. J. MacCoss, T. N. Davis, N. Isoherranen, A. Zelter

The paper introduces Magnum, an algorithm for identifying drug-protein adducts, and Limelight, a tool for analyzing and visualizing adduct data, validated with CYP3A4 examples.

bioRxiv · Jun 24, 2021Pharmacology & Toxicology

Novel phosphorylation states of the yeast spindle pole body

K. K. Fong, A. Zelter, B. Graczyk, J. M. Hoyt, M. Riffle, R. Johnson, M. J. MacCoss, T. N. Davis

The paper reports a phosphoproteomic analysis of yeast spindle pole bodies (SPBs) under two cell cycle conditions, identifying novel phosphorylation sites on γ-TuSC that regulate microtubule nucleation and spindle length.

bioRxiv · Jan 9, 2018Biochemistry

The human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore-microtubule attachments

L. A. Helgeson, A. Zelter, M. Riffle, M. J. MacCoss, C. L. Asbury, T. N. Davis

This study shows the Ska complex directly strengthens kinetochore-microtubule attachments by forming a load-bearing connection with the Ndc80 complex and microtubule tips.

bioRxiv · Jan 8, 2018Biochemistry