A. Ota

Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient malignant pleural mesothelioma

This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.

A mouse model of insomnia with sleep apnea

This paper develops a mouse model of comorbid insomnia and sleep apnea (COMISA) by inducing daytime hypoxia, showing a down-and-up activity response linked to sleepiness and insomnia.

LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis

This study identifies LUZP1 as a novel regulator of cytokinesis by modulating the constriction velocity of the contractile ring through interactions with DAPK3 and MYL9.

Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement

This study identifies a novel Mycobacterium avium subsp. hominissuis lineage in pigs that enables transmission route tracing through unique genetic features.

Genome-wide association study reveals putative bacterial risk factors for cavitary Mycobacterium avium complex lung disease

This study identifies bacterial genetic variants associated with cavitary Mycobacterium avium complex lung disease using genome-wide association analysis of clinical isolates.

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.

The paper analyzes 30 draft genomes of Mycobacterium avium subsp. hominissuis from Japanese pigs to characterize their genomic features and potential virulence.

Diversification of the restriction modification system of Streptococcus pyogenes through its acquisition of mobile elements

The paper analyzes methyltransferase diversity in Streptococcus pyogenes by comparing RM systems across genomes and suggests phage-derived MTases contribute to methylome diversity and gene regulation.