H. Konishi

Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo

This study identifies an antibody, CV804, that targets the conserved S2 domain of coronaviruses and shows broad cross-reactivity and ADCC activity against SARS-CoV-2 and related viruses.

A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a non-hemophiliac state

This paper reports a bispecific antibody NXT007 that shows improved hemostatic activity in hemophilia A monkeys, equivalent to FVIII levels, with lower dosing requirements and longer intervals.

LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis

This study identifies LUZP1 as a novel regulator of cytokinesis by modulating the constriction velocity of the contractile ring through interactions with DAPK3 and MYL9.

Deep Texture Representations as a Universal Encoder for Pan-cancer Histology

This paper introduces deep texture representations (DTRs) as a universal encoder for cancer histology, enabling accurate prediction of genomic features and cancer types from histological images.