S. Yoshida

Survivability and Life Support in Sealed Mini-Ecosystems with Simulated Planetary Soils

The paper explores sustainable life-support systems for space by simulating Earth ecosystems, identifying challenges like moisture and temperature, and highlighting microbial roles in ecosystem stability.

Human spermatogonial stem cells retain states with a foetal-like signature

This study identifies a foetal-like state 0B in human spermatogonial stem cells that maintains a suppressive transcriptomic program, contrasting with rodent models where this state is not maintained into adulthood.

A cellular assay system revealed the deamidase-mediated regulation of the Arg-mediated N-end rule protein degradation pathway

The paper develops an Arg-mediated N-end rule assay system to show that deamidase expression levels regulate protein degradation via the N-end rule pathway.

GTPase-activating protein ARAP1 regulates circular dorsal ruffles as a nutrient uptake mechanism in the Hep3B hepatocellular carcinoma cell line

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

Soil Prokaryotic and Fungal Biome Structures Associated with Crop Disease Status across the Japan Archipelago

The paper analyzes soil microbiome structures across Japan to identify microbial species sets associated with crop disease prevalence and suggests key microbes for managing disease-suppressive agroecosystems.

Growth and tension in explosive fruit

The paper investigates how tension in exploding seed pods of Cardamine hirsuta is generated through active cell growth and microtubule-controlled cellulose microfibril orientation.

Identification of Circular Dorsal Ruffles as Signal Platforms for the AKT pathways in Glomerular Podocytes

The paper identifies circular dorsal ruffles as signal platforms for the AKT-mTORC1 pathway in glomerular podocytes, linking them to kidney function and potential therapeutic targets.

Mechanical forces in extendable tissue matrix orient cell divisions via microtubule stabilization in Arabidopsis

The paper shows mechanical forces from tissue extension stabilize microtubules to orient cell divisions in Arabidopsis roots after wounding.

Basins of attraction of microbiome structure and soil ecosystem functions

The paper investigates basins of attraction in soil microbiome structure and their associations with ecosystem functions and crop disease prevalence.

Cytokinins induce prehaustoria coordinately with quinone and phenolic signals in the parasitic plant Striga hermonthica

This study shows cytokinins act as haustorium-inducing factors in Striga hermonthica but not in Phtheirospermum japonicum, and their signaling pathway overlaps with quinone and phenolic pathways.

Evolutionary relations between mycorrhizal symbiosis and plant-plant communication in trees

The paper investigates the link between mycorrhizal symbiosis types and plant-plant communication in trees, finding that ECM promotes communication among conspecifics.

Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement

This study identifies a novel Mycobacterium avium subsp. hominissuis lineage in pigs that enables transmission route tracing through unique genetic features.

Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants

This study identifies strigolactones as chemoattractants guiding host tropism in parasitic Orobanchaceae plants.

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

This study shows that oral S-217622 reduces SARS-CoV-2 viral load and improves recovery in hamsters, with activity against multiple variants.

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.

The paper analyzes 30 draft genomes of Mycobacterium avium subsp. hominissuis from Japanese pigs to characterize their genomic features and potential virulence.

Nitrates increase abscisic acid levels to regulate haustoria formation in the parasitic plant Phtheirospermum japonicum

This study shows nitrates inhibit haustoria formation in parasitic plants by increasing abscisic acid levels, with effects observed in both facultative and obligate parasites.

The Phtheirospermum japonicum isopentenyltransferase PjIPT1a regulates host cytokinin responses in Arabidopsis

This study identifies PjIPT1a as a key gene in Phtheirospermum japonicum that produces cytokinins to induce host hypertrophy during parasitism.

High and stable ATP levels prevent aberrant intracellular protein aggregation

This study shows that maintaining high and stable ATP levels prevents protein aggregation by showing that AMPK and ADK prevent ATP depletion and cytotoxic protein accumulation in yeast.

Computationally-efficient spatiotemporal correlation analysis super-resolves anomalous diffusion

This paper improves fcsSOFI by accelerating computation, expanding diffusion models, and enhancing usability to better analyze anomalous diffusion in porous media.

Preclinical study of DNA vaccines targeting SARS-CoV-2

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.

SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan

This study analyzes B cell epitopes and neutralizing activity in COVID-19 patients to identify potential vaccine targets.

Stable kinetochore-microtubule attachments restrict MTOC position and spindle elongation in acentrosomal oocytes

This study shows that stable kinetochore-microtubule attachments are crucial for positioning MTOCs at spindle poles and limiting spindle elongation in mouse oocytes.

Three-dimensional reconstructions of the internal structures of haustoria in parasitic Orobanchaceae

Three-dimensional image reconstruction was used to visualize the spatial organization of cell types in the haustoria of parasitic plants with special reference to their interaction with host roots.

Subtilase activity in the intrusive cells mediates haustorium maturation in parasitic plants

The study identifies subtilase activity in intrusive cells as critical for haustorium development and auxin-mediated host-parasite connections in Phtheirospermum japonicum.

Auxin transport network underlies xylem bridge formation between the hemi-parasitic plant Phtheirospermum japonicum and host Arabidopsis

A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis

This study identifies Arabidopsis SOSEKI proteins that integrate organismal axes to localize to polar cell edges and influence division orientation.

Dorsal Ruffles Enhance Activation of Akt by Growth Factors

The paper shows that dorsal ruffles enhance Akt phosphorylation by growth factors through cytoskeleton-dependent amplification of PI3K activity.

Loss Of PTEN Promotes Formation Of Signaling-Capable Clathrin-Coated Pits

This study shows PTEN regulates clathrin-coated pit dynamics by modulating PI(3,4,5)P3 levels, promoting short-lived signaling-capable CCPs in cancer cells.